The antileishmanial property of amarogentin, a secoiridoid glycoside isolated from the Indian medicinal plant Swertia chirata, was examined in a hamster model of experimental leishmaniasis. The therapeutic efficacy of amarogentin was evaluated in free and two different vesicular forms, liposomes and niosomes. The amarogentin in both liposomal and niosomal forms was found to be a more active lei...

Gene transfer to mesenchymal stem cells (MSCs) has arisen as a powerful approach increase the therapeutic potential of this effective cell population. Over recent years, niosomes have emerged self-assembled carriers with promising performance for gene delivery. The aim our work was develop niosomes-based DNA delivery platforms targeting MSCs. Niosomes based on 1,2-di-O-octadecenyl-3-trimethylam...

Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of Blood-Brain barrier other limitations oral routes administration makes drug delivery brain somewhat tricky. As a result, numerous novel systems being developed for brain. Howe...

At present days drugs are formulated by using different novel drug delivery system (NDDS) which are used for targeting drugs to different organ systems and for controlled /sustained release of drug from the dosage forms. The NDDS can be used to overcome many disadvantages of conventional dosage forms like poor bioavailability, first pass effect, systemic toxicity, degradation of drug in stomach...

Abstract: Background/Aim: Inflammation typically occurs when infectious microorganisms enter the body, settle in specific tissues, and/or circulate blood. Asparagus racemosus extract contains various saponins and flavonoids plant-origin drugs have fewer side effects toxicity. The phytoconstituents less permeability through skin; to enhance their effectiveness it was loaded niosomes. Therefore, ...

Abstract Background Docetaxel (DTX) has been used to treat numerous types of cancers. Poor solubility, lower bioavailability, and serious side effects limit its use in cancer treatment. The objective the present research work was develop DTX-loaded niosomes overcome these issues investigate anticancer effect on breast cancer. Niosomes DTX were prepared evaluated estimate particle size, surface ...

On admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media, microscopic lamellar structures formed are known as niosomes or non-ionic surfactant vesicles. Method of preparation of niosome is same as of liposome technology i.e. hydration by aqueous phase of the lipid phase which may be either a pure surfactant ...

Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant-based multilamellar or unilamellar ves...