BACKGROUND Voriconazole is frequently used to treat fungal infections in solid organ transplant patients. Recently, there have been reports suggesting that prolonged voriconazole therapy may lead to periostitis. AIM Here we present two cases of voriconazole-induced periostitis in solid organ transplant patients. CASE PRESENTATION Voriconazole was given to two transplant patients-one with a ...

The effects of carboxyacyl phosphatidylethanolamine derivatives (CA-PE) on the physicochemical properties of liposomes were examined from standpoints of zeta-potential, agglutination, phase transition temperature, microviscosity and micropolarity. Absolute zeta-potential of liposomes containing Succinyl-PE or Glutaryl-PE exceeded that of those containing Dodecanyl-PE. The addition of Succinyl-P...

In this research, two series of ultra-low cement high alumina refractory castables containing 0 and 0.4 wt.% of nano-titania were prepared using different amounts of polycarbonic acid (DOLAPIX FF 26) as a dispersant. Several characteristics including microstructure, flowability, mechanical strength, bulk density and apparent porosity of the samples were analyzed. The results showed that the opt...

Individual liposome measurements by capillary electrophoresis with postcolumn laser-induced fluorescence detection facilitated the determination of liposome property distributions, two-dimensional plots, and an improved characterization of a liposomal preparation. This advancement in liposome analysis was feasible by using a high-sensitivity postcolumn laser-induced fluorescence detector wired ...

Seed mediated aqueous chemical growth (ACG) route was used for the growth of ZnO nanostructures on Si substrate in four different growth mediums. The growth medium has shown to affect the morphology and the size of the different nanostructures. We observed that the medium containing zinc nitrate anions yields the nanorods, in a medium containing zinc acetate anions nano-candles are obtained. Wh...

BACKGROUND Incorporation of the solubilizing excipient, sulfobutylether-β-cyclodextrin (SBECD), in the intravenous (IV) formulation of voriconazole has resulted in the recommendation that this formulation be used with caution in patients with creatinine clearances (Clcr) < 50 mL/min. This study evaluated the safety of IV voriconazole compared with two other IV antifungals not containing SBECD i...

Voriconazole is a broad-spectrum triazole antifungal agent and the first-choice therapy for invasive aspergillosis (IA) (1). Although voriconazole is generally well tolerated, anecdotal case reports have described unexpected severe adverse events related to voriconazole, such as hyponatremia, which potentially could result in death (2–4). We report a case of successful voriconazole treatment of...