Background Tetralogy of Fallot is the most common cyanotic congenital heart disease. However, its pathogenesis remains to be clarified. The purpose of this study was to identify the genetic variants in Tetralogy of Fallot by whole exome sequencing. Methods Whole exome sequencing was performed among eight small families with Tetralogy of Fallot. Differential single nucleotide polymorphisms and...

An interactive computer program, LabHEART, was developed to simulate the action potential (AP), ionic currents, and Ca handling mechanisms in a rabbit ventricular myocyte. User-oriented, its design allows switching between voltage and current clamp and easy on-line manipulation of key parameters to change the original formulation. The model reproduces normal rabbit ventricular myocyte currents,...

An implicit, Navier-Stokes solution algorithm is presented for the computation of turbulent flow on unstructured grids. The inviscid fluxes are computed using an upwind algorithm and the solution is advanced in time using a backward-Euler time-stepping scheme. At each time step, the linear system of equations is approximately solved with a point-implicit relaxation scheme. This methodology prov...

Leading edge noise is a significant broadband noise source in aircraft engines, and is the primary broadband noise mechanism in outlet guide vane noise in turbofans, and broadband rotor wake interaction noise in contra-rotating open rotor engines. Previous authors have studied the effects of various aspects relating to this noise source, including airfoil geometry effects, cascade effects, and ...

The objective of this study is to numerically investigate the fundamental roles that momentum and vorticity injections play in suppressing flow separation over a canonical airfoil. Open-loop control of separated, incompressible flow over a NACA 0012 airfoil at Re = 23, 000 is examined through large-eddy simulations. In particular two conditions are considered: (1) α = 6◦ – shallow stall and (2)...

The fact that injuries caused by accidents are the most common cause of death in children and adolescents in Germany gave rise to the study, which mainly deals with traffic accidents in this group. 200,221 records of emergency-service physicians in Bavaria which cover the period 1995-1999 were analysed with respect to the importance of traumatic brain injury (TBI) in children and adolescents (n...

O objetivo deste estudo foi análise numérica, via simulação realizado no ANSYS Fluent em um aerofólio de perfil NACA 4415 com variações ângulos ataque. Analisou-se a distribuição pressão e velocidade do fluido ao redor da estrutura, bem como os valores coeficientes arrasto sustentação. Por meio das equações modelo turbulência denominado Spalart-Allmaras possível encontrar as tensões turbulentas...