Nascent polypeptide-associated complex (NAC) was initially found to bind to any segment of the nascent chain except signal sequences. In this way, NAC is believed to prevent mistargeting due to binding of signal recognition particle (SRP) to signalless ribosome nascent chain complexes (RNCs). Here we revisit the interplay between NAC and SRP. NAC does not affect SRP function with respect to sig...

The production of reactive oxygen species in skeletal muscle is linked with muscle fatigue. This study investigated whether the antioxidant compound N-acetylcysteine (NAC) augments time to fatigue during prolonged, submaximal cycling exercise. Seven men completed a double-blind, crossover study, receiving NAC or placebo before and during cycling exercise, comprising 45 min at 70% of peak oxygen...

Abstract This article presents the experimental results of compressive strength, splitting tensile macro destruction mode, and microstructure recycled clay brick aggregate concrete (RBC) with different (RBA) replacement rates. The show that strength RBC are lower than those natural (NAC), but effect RBA on is not significant. water–cement ratio (w/c) smaller NAC. shows a trend first decreasing ...

In recent decades, new administrative capitals (NACs) are being developed in Asia and developing countries due to the overcrowding of large cities. The self-sufficiency a planned city is considered important for balanced national development. However, no study has specifically analyzed degree NACs. Therefore, focusing on Sejong (NAC, South Korea) as an example, this evaluated using data regardi...

Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. The NAc receives glutamatergic inputs from the medial prefrontal cortex (mPFC), ventral hippocampus (vHIP) and basolateral amygdala (AMY). Here, we de...

Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20%...

Drug induced liver injury (DILI) leads to acute hepatitis in 10%, liver failure, and death in 30%. One of the major drugs causing DILI is Anti-tuberculous drugs and since tuberculosis is affecting 1/3rd of the total world population, their use is quite common. Use of Isoniazid (INH) is limited owing to hepatotoxicity following the stress produced by oxidative species. Silymarin has hepatoprotec...

Rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produceshepatic, renal and bone marrow toxicity in human and animals. In this study, the protectiveeffects of vitamin C and n-acetylcysteine (NAC) on the toxicity of rifampin on HepG2 cellswere investigated.Human hepatoma cells (HepG2) were cultured in 96-well M of rifampin in the presence ofmicroplate and expose...