The heat-induced conversion of 5-methylcytosine (m5C) residues to thymine residues and of cytosine to uracil residues in single-stranded DNA was studied. The calculated rates for deamination at 37 degrees C and pH 7.4 were approximately 9.5 X 10(-10) and 2.1 X 10(-10) sec-1, respectively. N4-Methyldeoxycytidine, which is in the DNA of certain thermophilic bacteria, was more heat-resistant than ...

This paper describes a range of theoretical studies into the likely properties of poly-nitrogen molecules (Nn, n>3). In particular, we describe the approach we have used to assess the potential detonation performance of this class of material, and illustrate this with a number of example calculations. We also discuss the implications and limitations of these predictions. In addition, we describ...

Given a Euclidean graph G in Rd with n vertices and m edges, we consider the problem of adding an edge to G such that the stretch factor of the resulting graph is minimized. Currently, the fastest algorithm for computing the stretch factor of a graph with positive edge weights runs in O(nm+n2 log n) time, resulting in a trivial O(n3m+n4 log n) time algorithm for computing the optimal edge. Firs...

We present a fluid dynamics video showing the behavior of Leidenfrost droplets composed by a mixture of water and surfactant (SDS, Sodium Dodecyl sulfate). When a droplet is released on a plate heated above a given temperature a thin layer of vapor isolates the droplet from the plate. The droplet levitates over the plate. This is called the Leidenfrost effect. In this work we study the influenc...

A mononuclear nonheme ferric-peroxo complex bearing a macrocyclic tetradentate N4 ligand, [(TMC)Fe(III)-O2]+, was prepared and used in mechanistic studies of aldehyde deformylation; a catalytic aldehyde deformylation by a nonheme iron(II) complex, [Fe(II)(TMC)]2+, and molecular oxygen is reported as well.

Structure and properties of magnesium silicate borate melts glasses were investigated by using newly parameterized interaction potentials in molecular dynamics simulations compared with those calcium borate. The competition between the depolymerization silica network formation new bonds modifier ions leads to enhancement elastic moduli increasing content alkaline earth glasses. Compared silicat...

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The Roseophages, a group of marine viruses that uniquely infect the Roseobacter clade of bacteria, play a significant role in marine ecosystems. Here we present a complete genomic sequence of an N4 phage 'vB_DshP-R1', which infects Dinoroseobacter shibae DFL12, together with its structural and genomic features. vB_DshP-R1 has an ~ 75 nm diameter icosahedral structure and a complete genome of 75...

The phage T4Dam and EcoDam DNA-[adenine-N6] methyltransferases (MTases) methylate GATC palindromic sequences, while the BamHI DNA-[cytosine-N4] MTase methylates the GGATCC palindrome (which contains GATC) at the internal cytosine residue. We compared the ability of these enzymes to interact productively with defective duplexes in which individual elements were deleted on one chain. A sharp decr...