Background There is a strong association between gout and kidney disease due to the kidney’s key role in uric acid excretion. 1-4 Several studies have also demonstrated that serum an independent risk factor for decline renal function 1,2 . are little national data available regarding clinical burden of patients US. Objectives To estimate percentage US hospitalizations with concomitant diagnosis...

BACKGROUND Analysis of hospital mortality helps to assess the standards of health-care delivery. METHODS This is a retrospective cohort study evaluating the causes of deaths which occurred during the years 1995-1999 in a single hospital. The causes of death were classified according to the International Statistical Classification of Diseases (ICD-10). RESULTS Of the 149,896 patients who wer...

During human pregnancy, the production of 17-beta-estradiol (E2) rises steadily to eighty fold at term, and placenta has been found to specifically bind estrogens. We have recently demonstrated the expression of estrogen receptor alpha (ER-alpha) protein in human placenta and its localization in villous cytotrophoblast (CT), vascular pericytes, and amniotic fibroblasts. In vitro, E2 stimulated ...

Andes virus (ANDV) predominantly infects microvascular endothelial cells (MECs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome (HPS). In HPS patients, virtually every pulmonary MEC is infected, MECs are enlarged, and infection results in vascular leakage and highly lethal pulmonary edema. We observed that MECs infected with the ANDV hantavirus or expressin...

Immune escape is a fundamental trait of cancer. Dendritic cells (DC) that interact with T cells represent a crucial site for the development of tolerance to tumor antigens, but there remains incomplete knowledge about how DC-tolerizing signals evolve during tumorigenesis. In this study, we show that DCs isolated from patients with metastatic or locally advanced breast cancer express high levels...

Abstract Background and Aims The estimated glomerular filtration rate (eGFR) other kidney function markers are associated with cardiovascular disease (CVD) mortality [1]. It remains unclear whether integrating multiple together can improve CVD risk prediction what would be an appropriate method of integration. In a small general population sample, we recently showed that confirmatory factor ana...

National policy in the UK emphasises the importance of involving service users and caregivers in all types of mental health provision. The training of mental health care and social service professionals has always relied on seeing patients, but the patients’ role has usually been a passive one. This is now changing, and service users and carers are becoming active educators in professional trai...

Three-body interactions in a homonuclear van der Waals bound trimer ~the 1 A28 state of Na3) are studied spectroscopically for the first time using laser induced emission spectroscopy on a liquid helium nanodroplet coupled with ab initio calculations. The van der Waals bound, spin polarized sodium trimers are prepared via pickup by, and selective survival in, a beam of helium clusters. Laser ex...