Infants born to atopic parents have been found to be at high risk of allergy development. The present study investigated the effect of a maternal milk-free diet during late pregnancy and lactation on the immune response and allergy incidence in at-risk and control infants. Atopic mothers were randomly allocated into an intervention group (n 12) or an unrestricted-diet group (n14) and compared w...

The spermine analogues, N1,N12-bis(ethyl)spermine (BESPM), N1,N11-bis(ethyl)norspermine (BENSPM), and N1,N14-bis(ethyl)-homospermine (BEHSPM) behave similarly in down-regulating the key polyamine biosynthetic enzymes, ornithine and S-adenosylmethionine decarboxylase, but differ distinctly in their abilities to induce the polyamine catabolic enzyme, spermidine/spermine-N1-acetyltransferase; BENS...

Economic Conditions at the Time of Birth and Cognitive Abilities Late in Life: Evidence from Eleven European Countries With ageing populations and a stronger reliance on individual financial decision-making concerning asset portfolios, retirement schemes, pensions and insurances, it becomes increasingly important to understand the determinants of cognitive ability among the elderly. Macro-econo...

BACKGROUND As population and access to information increases, so does the demand for health services. Unfortunately, many people who genuinely require these services do not usually have access to them. To increase access, various financing options have been used. Despite this, maternal morbidity and mortality rates remain high and spending is still largely out of pocket. This study assesses mat...

Re-denomination was not only a zero dropping and new coin minting operation but also a significant milestone in Turkey. Before the currency reform, multiple zeros had posed several difficulties in expressing monetary values, transactions, bookkeeping and statistical records, data processing software, payment systems, price labels etc. So, removing six zeros from national currency became a ...

The most commonly occurring of the natural polyamines are putrescine [ Nl ll(CI ll),N14?, a diaminel, spermidine [ Nl 12(C€12)3Nl l(C142),NIIl. a triamine] and spermine [ Nl il(Cl 12);NI l(C€Il),N€I(CI 1?)?NI ?. a tetramine]. One or more of these compounds are present in every living cell. All are found in eukaryotes; spermine is absent from most prokaryotes. The polyamines are essential for ce...

In the 1960s, yellowing symptoms in sugarcane were seen throughout East Africa. This was called ‘yellow-wilt’, a condition first described in Tanzania in 1962. The symptoms appear identical to those of Yellow Leaf Syndrome (YLS). In South Africa symptoms of YLS were first observed in 1994 and were conspicuous in varieties CP66/1043, N22 and N26, intermediate in N27 and less conspicuous in NCo37...

As an antiproliferative strategy, we are using bis(ethyl) derivatives of spermine to suppress polyamine biosynthetic enzyme activity and, thereby, deplete intracellular polyamine pools. Since certain of these analogues have recently been shown to potently increase spermidine/spermine-N1-acetyltransferase activity, we have investigated the relationship of this effect to growth inhibition and pol...