The title compound, [Mg(C(6)H(5)N(2)O(4))(2)(H(2)O)(2)], was prepared by reaction of Mg(NO(3))(2) and 2-methyl-1H-imidazole-4,5-dicarboxylic acid under hydro-thermal conditions. The Mg(II) atom lies on an inversion centre and displays a distorted octa-hedral coordination geometry. An extended three-dimensional network of inter-molecular O-H⋯O and N-H⋯O hydrogen bonds stabilizes the crystal stru...

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concent...

N-Hydroxylation and mutagenic activation of heterocyclic aromatic amines from protein pyrolysis products were studied in rat liver microsomes and nuclei, rat hepatocytes and various species of purified cytochrome P-450. These mutagenic amines include Trp-P-2 (3-amino-1-methyl-5H-pyrido[4,3-b]indole), Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole), Glu-P-1 (2-amino-6-methyldipyrido-[1,2-a...

The asymmetric unit of the title complex, [Ni(C(12)H(8)N(2))(3)][NiCl(3)(C(7)H(12)N(2)S)](2)·2CH(3)CN, consists of one anion, one-half of a cation and one acetonitrile mol-ecule. The Ni(II) atom in the [Ni(phen)(3)](2+) cation (phen is 1,10-phenanthroline) lies on an inversion centre in an octa-hedral environment, whereas in the [NiCl(3)(tm)](-) anion [tm is 1-tert-butyl-imidazole-2(3H)-thione]...

Ammoxidation of technical lignins under mild conditions is a suitable approach to artificial humic substances. However, carbohydrates as common minor constituents of technical lignins have been demonstrated to be a potential source of N-heterocyclic ecotoxic compounds. Ethyl acetate extracts of ammoxidation mixtures of the monosaccharides glucose and xylose exhibited considerable growth inhibit...

In the deoxy ferrous state of histidine-ligated heme proteins, the iron-histidine band (νFe-His) has been assigned as a stretching mode that involves a two-body motion involving the iron and histidine combined with a minor amount of heme doming. An analogous Raman band, νFe-L has been observed in the proximal cavity mutant of H93G myoglobin where the Raman band of a series of nonnative axial li...

      In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at c...

The fluorescence from tetramethyl rhodamine in hairpin polyamide tetramethyl rhodamine (TMR) conjugates is quenched in solution. TMR fluoresces brightly upon polyamide binding match DNA. Similar behavior is not observed in the presence of mismatch DNA; the hairpin polyamide-fluorophore conjugates therefore provide a smallmolecule fluorescent means for detecting chosen DNA sequences in homogenou...

O-Benzylguanine (BG) effectively inactivates the DNA repair protein O-alkylguanine-DNA alkyltransferase and enhances the effectiveness of alkylating agents, such as 1,3bis(2-chloroethyl)-1-nitrosourea and temozolomide, in vitro and in vivo. BG is presently in clinical trials with 1,3-bis(2chloroethyl)-1-nitrosourea and temozolomide. Preclinical data demonstrate that BG enhances the sensitivity ...