The first step in metabolic activation of mutagenic and carcinogenic heterocyclic amines has been elucidated to be N-hydroxylation by cytochrome P-448. N-Hydroxyamino compounds are further activated to form N-O-acyl derivatives that readily react with DNA. The adducts between the metabolites of Trp-P-2 and Glu-P-1 and DNA were shown to have a C8-guanylamino structure. In the case of Glu-P-1, mo...

The electronic structures and photophysical properties of eight Pt-complexes with different N-heterocyclic carbene ligands and potential to serve as light emitting diode materials were investigated by density functional theory and time-dependent density functional theory, employing the BP86 functional for geometry optimisations, SAOP potential for excited state calculations and all-electron TZ2...

The head-to-tail dimerization of N-heterocyclic diazoolefins is described. products these formal (3+3) cycloaddition reactions are strongly reducing quinoidal tetrazines. Oxidation the tetrazines occurs in a stepwise fashion, and we were able to isolate stable radical cation diamagnetic dications. latter also accessible by oxidative diazoolefins.

Porphyrins and N-heterocyclic carbenes (NHCs) are both relevant ligands in the fields of coordination organometallic chemistry. Despite evident structural differences, porphyrins NHCs have a lot common such as their ability to form strong metal-ligand bonds use catalysis, materials science biomedicine. During last decade, several molecular systems combining NHC were reported literature. The pre...

N -tert -butyliminodiacetic acid (H2TEBIDA, compound 1) has been prepared and characterised by thermogravimetric analysis, FT-IR and NMR spectra, and X-ray crystallography (final R1 /0.04). The zwitterion H2TEBIDA 9 is intra -stabilised by a hydrogen bond, and H-bonded chains of zwitterions form supramolecular 2D bilayers with tert -Bu groups towards the external faces. Compounds [Cu(TEBIDA)(H2...

Controlling the reactivity and stability of graphene-supported Ru NPs by modifying their surface with pyrene-tagged N -heterocyclic carbene ligands.

Correction for ‘Advances in chemistry of N-heterocyclic carbene boryl radicals’ by Tsuyoshi Taniguchi, Chem. Soc. Rev. , 2021, DOI: 10.1039/d1cs00385b.