Results In 54 patients the mean age at the first symptom was 117.50±45.20 months. BD was suspected at a mean age of 143.56±39.63 months. The mean delay between the first symptom and BD suspicion was 27.36±27.15 months. The most common manifestations were oral ulcer 96.3% (n=52), uveitis 46.3% (n=25), genital ulcer 37% (n=20), pustuler lesion 37% (n=20), erythema nodosum 24.1%(n=13) respectively...

and Applied Analysis 3 The nonlinear local fractional equation reads as L α u + N α u = 0, (19) where L α and N α are linear and nonlinear local fractional operators, respectively. Local fractional variational iteration algorithm can be written as [37] u n+1 (t) = u n (t) + t0 I t (α) {ξ α [L α u n (s) + N α u n (s)]} . (20) Here, we can construct a correction functional as follows [37]: u n+1 ...

This review considers the definition of a healthy bone phenotype through the life course and the modulating effects of muscle function and nutrition. In particular, it will emphasise that optimal bone strength (and how that is regulated) is more important than simple measures of bone mass. The forces imposed on bone by muscle loading are the primary determinants of musculoskeletal health. Any f...

Although lumbar instability is considered to be responsible for the majority of chronic or recurrent backaches, the word ‘instability’ is still poorly defined. A number of different definitions exist, but as yet there are no clear and validated clinical features by which instability might be diagnosed. It is also not clear how instability as such might set up pain and disability. It is generall...

Recent studies in laboratory rodents have revealed that circadian oscillation in the physiologic functions affecting drug disposition underlies the dosing time-dependent change in pharmacokinetics. However, it is difficult to predict the circadian change in the drug pharmacokinetics in a diurnal human by using the data collected from nocturnal rodents. In this study, we used cynomolgus monkeys,...

Three of thirty-six monoclonal antibodies were found to cause irreversible inactivation of type 1 poliovirus at 39 degrees C but not at 37 degrees C. Neutralization at 37 degrees C depended on aggregation and was reversible by acid-induced deaggregation; at 39 degrees C, the virions (N antigenic, 160S) were disrupted to empty capsids (H antigenic, 100S), and neutralization was irreversible. The...