Background: IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma. Objective: To determine the role of IL-17 in predicting severe asthma. Methods: We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (...

We study dynanics of $SU(N-4)$ gauge theories with fermions in rank-2 symmetric tensor and $N$ anti-fundamental representations, by perturbing supersymmetric anomaly-mediated supersymmetry breaking. find the $SU(N)\times U(1)$ global symmetry is dynamically broken to $SO(N)$ for $N\geq 17$, a different result from conjectures literature. For $N<17$, flow infrared fixed points.

Early intervention by teams specialising in the treatment of early psychosis has been suggested to enhance outcome in the early phase of psychotic illness. Two papers in the Journal address this topic. The first examines the cost-effectiveness of these services, while the second examines the 5-year outcome of one such service. McCrone and colleagues (pp. 377–382) report that although their spec...

AMA Kashuba N, Melnyk N. DETERMINATION OF THE EPIDEMIC THRESHOLD AN INFECTIOUS DISEASE. Health Problems of Civilization. 2023;17(2):122-129. doi:10.5114/hpc.2023.126726. APA Kashuba, N., & Melnyk, (2023). Civilization, 17(2), 122-129. https://doi.org/10.5114/hpc.2023.126726 Chicago Nikolay, and Nataliia Melnyk. 2023. "DETERMINATION DISEASE". Civilization 17 (2): Harvard pp.122-129. MLA Nikolay ...

The title compound, C(24)H(30)O(5), is the didehydro product of the steroid hellebrigenin (systematic name: 3β,5,14-trihy-droxy-19-oxo-5β-bufa-20,22-dienolide). It consists of three cyclo-hexane rings (A, B and C), a five-membered ring (D) and a six-membered lactone ring (E). The stereochemistry of the ring junctions are A/B cis, B/C trans and C/D cis. Cyclo-hexane rings A, B and C have normal ...

This paper describes a convenient approach to the 7-aza-des-A-steroid (6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[h]quinoline) scaffold starting from Grundmann's ketone using two different pyridine annulation protocols. The biological evaluation of the pyridine and pyridinium products revealed that these compounds unexpectedly do not interfere with ergosterol and cholesterol biosynthesis. The pyridi...

Cross-linked nanoassemblies (CNAs) with a degradable core were prepared for sustained release of 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), a potent inhibitor of heat shock protein 90 (HSP90). The particle size of CNAs ranged between 100 and 250 nm, which changed depending on the cross-linking yields and drug entrapment method. CNAs with a 1% cross-linking yield entrapped 17-AAG in aque...