PURPOSE The CTNND2 gene is located in the linkage interval of high myopia locus MYP16 and two single-nucleotide polymorphisms (SNPs; rs6885224 and rs12716080) in CTNND2 were recently shown to associate with high myopia. This study evaluated such associations in an independent case-control series. METHODS A total of 2773 unrelated individuals were enrolled in this study, including 1203 subject...

PURPOSE To determine the prevalence, incidence, and progression of myopia of Chinese children in Hong Kong. METHODS A cross-sectional survey was initially conducted. A longitudinal follow-up study was then conducted 12 months later. RESULTS A total of 7560 children of mean age 9.33 (95% confidence interval [CI] = 9.11-9.45; range, 5-16) participated in the study. Mean spherical equivalent r...

The purpose of this work was to investigate quantitatively the interactions between accommodation, vergence and a mechanism of emmetropization driven by optical blur within the retinal image with a view to developing a model that provides an explanation of both normal emmetropization and near-work associated myopia. The simulations of the change in the refractive state of the eye over time that...

PURPOSE To quantify the degree of association between juvenile myopia and parental myopia, near work, and school achievement. METHODS Refractive error, parental refractive status, current level of near activities (assumed working distance-weighted hours per week spent studying, reading for pleasure, watching television, playing video games or working on the computer), hours per week spent pla...

PURPOSE Matrix metalloproteinase 2 (MMP2) has been shown to be expressed in the human sclera, and is increased in the sclera of the eye with myopia induced by form deprivation in chicks when compared with the control eye. The purpose of this study was to examine the relationship between high myopia and MMP2 in a mainland Han Chinese population. METHODS Four hundred unrelated patients with hig...

OBJECTIVE To determine the correlation between multifocal electroretinogram (mfERG) parameters and the severity of myopia in adults and children. DESIGN Observational study. METHODS Multifocal electroretinograms were recorded using the VERIS system from randomly selected eyes of 104 children and 31 adults with various degrees of myopia. Dawson, Trick, and Litzkow fiber electrodes were used ...

CONTEXT The development of myopia and growth of the eye, occur at a time when body stature is increasing. AIMS To investigate the relationship of lifestyle and body growth with axial elongation and myopia development among schoolchildren aged 7 to 9 years. SETTINGS AND DESIGN Prospective study. MATERIALS AND METHODS Children in elementary schools without serious eye disorders were invited...

PURPOSE Myopia is the most common visual problem in the world. High myopia, the extreme form of myopia that can be complicated by retinal detachment and macular degeneration, affects 1%-2% of the general population. The genes responsible for nonsyndromic high myopia have not been identified although several chromosome loci have been suggested. Additional loci for the majority of high myopia, es...

BACKGROUND Many efforts have been invested in slowing progression of myopia. Among the methods, atropine administration and orthokeratology (OK) are most widely used. This study analyzed the efficacy of atropine and OK lens in controlling myopia progression and elongation of axial length. METHODS This retrospective study included 105 patients (210 eyes) who wore OK lenses and 105 patients (21...

1 Associate Professor Department of Ophthalmology, Centre for Eye Research Australia, University of Melbourne, Australia Department of Ophthalmology, National University of Singapore Singapore Eye Research Institute Singapore National Eye Centre 2 Associate Professor Department of Community, Occupational and Family Medicine, National University of Singapore Department of Ophthalmology, National...