BACKGROUND Glucagon-like peptide-1 (GLP-1) and its mimetics reduce infarct size in the setting of acute myocardial ischemia/reperfusion (I/R) injury. However, the short serum half-life of GLP-1 and its mimetics may limit their therapeutic use in acute myocardial ischemia. Domain antibodies to serum albumin (AlbudAbs) have been developed to extend the serum half-life of short lived therapeutic p...

1. To recognise that acute myocardial ischaemia/reperfusion injury is a neglected therapeutic target for cardioprotection that is responsible for the ongoing morbidity and mortality of patients with ischaemic heart disease. 2. To be aware that cardiac bypass surgery and STEMI are the major clinical settings in which the heart is subjected to acute ischaemia/reperfusion injury. 3. To be familiar...

BACKGROUND Myocardial Infarction and Ischaemic stroke are potential outcome after an electric shock though it is seen relatively rarely. CASE REPORT Here, we report a man with myocardial infarction as well as Ischaemic stroke occurring together who suffered a domestic low- voltage (220-240V) electrical injury. Myocardial infarction was evident by cardiac enzymes, electrocardiography and echoc...

To establish an HPLC method for determination of tanshinone IIA in Salvia miltiorrhiza Bunge extract, and observe the protective effect of Salvia miltiorrhiza extract on myocardial ischemia-reperfusion injury in rats. Column used is a Diamonsil C18, mobile phase is methanol-water (75:25), and detection wavelength is 270 nm. Ischemia-reperfusion injury model is replicated, and the size of myocar...

Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only the heart, but also remote organs. In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue. In response to myocardial ischemia/reperfusion injury in the mo...

Objective: To study the protective effect of Esculetin on myocardial injury induced by doxorubicin and explore mechanism in rats. Methods: Doxorubicin(2.5mg/kg) was injected intraperitoneally every other day for 6 times to establish a rat model injury. The effects different doses (10mg/kg & 20mg/kg) serum enzymes tissue were observed. Results: Doxorubicin significantly increased content int...

Acute pancreatitis is an inflammatory disease characterized by local tissue injury which can trigger a systemic inflammatory response. Vascular complications of pancreatitis are a major cause of morbidity and mortality. Pulmonary embolism in acute pancreatitis has been reported to be very rare. Cardiovascular complications include shock, hypovolemia, pericardial effusion, and even nonspecific S...

AIM SB-710411 is a rat selective urotensin-II (U-II) receptor antagonist, which can block U-II-induced contraction of the aorta and inhibit U-II-induced myocardial fibrosis in rats. However, the effect of SB-710411 on myocardial ischemia-reperfusion (I/R) injury is unclear. The present study was designed to investigate whether SB-710411 has a protective effect on myocardial I/R injury in rats a...

The effects of schisandrin B (Sch B), curcumin, epigallocatechin gallate (EGCG) and resveratrol on the glutathione regeneration capacity (GRC) of liver and heart tissues ex vivo were examined in relation to their protective effects against CCl4 hepatotoxicity in vivo and myocardial ischemia/reperfusion (I/R) injury ex vivo in rats. Results indicated that Sch B, but not curcumin, EGCG or resvera...

Abstract The consequences of myocardial infarction (MI) are an increasing problem worldwide. Despite spectacular progress in the invasive treatment ischemic heart disease, ability to limit ischemia-reperfusion (I/R) injury remains largely unrealized. Recent studies have shown that stimulation opioid receptors may confer a cardioprotective effect against I/R injury. Levosimendan, inodilator, is ...