Cardiac hypertrophy was produced in rats by banding the ascending aorta. Increases in heart weight and RNA content occurred within 48 hours, indicating that hypertrophy develops rapidly. The total RNA content and the specific radioactivity of RNA labeled with H-uridine were determined. The rate of RNA synthesis was estimated from these data and from the specific radioactivity of the myocardial ...

The specificity and significance of the asymmetric septal hypertrophy (ASH) and myocardial fiber disarray of idiopathic hypertrophic subaortic stenosis (IHSS) is uncertain. To examine this we studied 215 hearts, including normal embryos, fetuses, children, and adults; and hearts with congenital and acquired disease. Disproportionate septal thickening was present in all embryos and in some abnor...

THE TERM primary myocardial disease refers to a variety of cardiac enlargement which is of unknown cause and frequently leads to cardiac dilatation, congestive heart failure, and finally to death. There are a number of synonyms. The disorder is also called idiopathic myocardial hypertrophy,' myocardiopathy, cardiac hypertrophy of unknown cause, and, especially in Great Britain, cardiomyopathy. ...

BACKGROUND Metabolism remodeling has been recognized as an early event following cardiac pressure overload. However, its temporal association with ventricular hypertrophy has not been confirmed. Moreover, whether trimetazidine could favorably affect this process also needs to be determined. The aim of the study was to explore the temporal changes of myocardial metabolism remodeling following pr...

Background Aortic stenosis (AS) appears to be not just a disease of the valve, with adaptive and maladaptive myocardial remodeling playing a key role. Left ventricular (LV) remodeling in AS is characterized by cellular hypertrophy and diffuse myocardial fibrosis. Macroscopic patterns differ between patients: as hypertrophy increases, the pattern changes from normal to concentric remodeling, con...

BACKGROUND Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging is increasingly used to assess myocardial involvement in patients with Fabry disease, an X linked lipid storage disorder. However, it is often proposed as an optional tool. A different cardiomyopathic disease progression between male and female patients was hypothesised in previous studies, as in f...

Hypertension is associated with atherosclerosis and cardiac and vascular structural and functional changes. Myocardial ischemia may arise in hypertension independent of coronary artery disease through an interaction between several pathophysiological mechanisms, including left ventricular hypertrophy, increased arterial stiffness and reduced coronary flow reserve associated with microvascular d...

OBJECTIVE To assess the association between cardiovascular risk factors and acute myocardial infarction as the first manifestation of ischemic heart disease, correlating them with coronary angiographic findings. METHODS We carried out a cross-sectional study of 104 patients with previous acute myocardial infarction, who were divided into 2 groups according to the presence or absence of angina...

Six of 14 patients with hemodynamically proven subaortic stenosis (SAS) showed electrocardiographic patterns consistent with myocardial infarction. Analysis of the 0.02-sec horizontal plane vector allowed discrimination between true myocardial infarction and SAS. In SAS this vector was shifted anteriorly and to the right consistent with septal hypertrophy and increased left-to-right early septa...