Anginal symptoms and electrocardiographic changes suggestive of myocardial ischemia, despite angiographically normal coronary arteries, are common in patients with cardiomyopathies and those with left ventricular hypertrophy secondary to pressure overload. Studies using positronemission tomography (PET) to measure regional myocardial blood flow have demonstrated that maximum myocardial blood fl...

We report a 71-year-old woman with takotsubo-like myocardial dysfunction accompanied with cerebellar hemorrhage. On admission time, although she was unconscious by cerebellar hemorrhage, no obvious heart failure and serological disorder were observed. Three days later, operation for extraventricular drainage was performed. However, conscious level did not change. Four days after admission, the ...

Background MRI-derived T1 times are associated with diffuse interstitial myocardial fibrosis. LV diastolic dysfunction and fibrosis are important components of cardiac disease, but their relationship has not been firmly established. Early diastolic strain rate (Epeak) has been validated as an indicator of diastolic function by tagged MRI. We derive a novel strain relaxation index (SRI) based on...

OBJECTIVES To review mechanisms underlying sepsis-induced cardiac dysfunction in general and intrinsic myocardial depression in particular. DATA SOURCE MEDLINE database. DATA SYNTHESIS Myocardial depression is a well-recognized manifestation of organ dysfunction in sepsis. Due to the lack of a generally accepted definition and the absence of large epidemiologic studies, its frequency is unc...

Although myocardial depression is the predominant cause of death in severe sepsis/septic shock, it remains disputed whether the functional changes are a consequence of structural alterations. If we look at myocardial dysfunction from the perspective of a critically ill patient, there are a few questions to be asked: What causes myocardial dysfunction? What is the pathophysiology of cardiac dysf...

EDITORIAL Myocardial dysfunction in sepsis is a complex entity due to the dynamic adaptation of the cardiovascular system to the disease process, the host response, and the effects of resuscitation. The pathophysiology of this entity is multifactorial; systemic, cellular, and extracellular mechanisms have been described, including maldistribution of coronary blood flow, myocardial injury, compl...

Clinical and experimental studies indicate an association between diabetes mellitus and myocardial dysfunction, eventually leading to congestive heart failure irrespective of the presence or absence of arterial hypertension and coronary artery disease. However, myocardial dysfunction due to diabetes mellitus, referred to as “diabetic cardiomyopathy,” is not generally accepted as a distinct clin...

Background: There are some conflicting results with Conventional Coronary Artery Bypass Grafts (CCABG) with arrested heart in coronary high-risk patients. Moreover, performing off-pump CABG in these cases may be associated with serious complications. The objective of this study is to evaluate the efficacy of the on-pump beating CABG (OPBCABG) in coronary high-risk patients in comparison with th...