نتایج جستجو برای: mutagenicity
تعداد نتایج: 3111 فیلتر نتایج به سال:
The aim of this study was to assess the interaction of a series of well characterised nano-objects with the Gram negative bacterium Salmonella typhimurium, and how such an interaction may relate to the potential mutagenicity of nano-objects. Transmission electron microscopy showed that nano-objects (Au-PMA-ATTO NPs, CeO₂ NPs, SWCNTs and MWCNTs), as well as CAFs entered S. typhimurium. Only DEPs...
At the request of the European Food Safety Authority, the Scientific Committee has reviewed the 8 current state-of-the-science on genotoxicity testing strategies and provided a commentary and 9 recommendations on testing strategies, bearing in mind the needs of EFSA’s various Scientific Panels 10 to have appropriate data for risk assessment. It is hoped that this opinion will contribute to grea...
We tested the proposition that human mammary lipid contains muta genic/genotoxic agents that could cause DNA damage in adjacent epithe. hal cells. Lipid samples from breast tissue surgically removed from 40 women undergoing elective reduction mammoplasty were extracted by a solid-phase procedure. Mutagenicity was observed in Salmonella typhi murium TA98 and TA1538 in 16 of 40 (40%) extracts ass...
To evaluate chemical safety, many kinds of short-term mutagenicity assays are performed together with long-term assays in animals. Rationales and methodology for these assays have been well discussed and documented. No statistical method, however, has been singled out as the method of choice for the evaluation of mutagenicity assay data, although a number of reports on statistical methods to ev...
Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni.
Leaves of Stevia rebaudiana Bertoni have been popularly used as a sweetener in foods and beverages for diabetics and obese people due to their potent sweetener stevioside. In this report, stevioside and steviol were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 and for chromosomal effects on cultured human lymphocytes. Stevioside was not mutagenic at concentrations up...
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