OBJECTIVES Thin muscle fibers on transurethral resection of the bladder (TURB) can represent either muscularis propria destroyed or splayed by urothelial carcinoma or muscularis mucosae, which can be hyperplastic. METHODS The data from 94 patients with invasive bladder cancer seen at our institution (1986-2008) with a mean of 25.4 months of follow-up, who had had an uncertain pathologic diagn...

The three-dimensional organization of the lymphatics in the dog stomach was studied by scanning electron microscopy of corrosion casts, which were made by direct parenchymal injection of low-viscosity Mercox-resin into the mucosa and the muscular layers. Although the organization of lymphatics in the stomach has been studied by a variety of methods, the origin of the lymphatics and their connec...

The three-dimensional ultrastructure of the autonomic nerve terminals in the lamina propria mucosae of the rat large intestine was studied by scanning electron microscopy using the KOH-collagenase digestion method as well as by transmission electron microscopy. Observations showed unmyelinated nerves in the lamina propria mucosae as well developed just above the muscularis mucosae and forming a...

The opossum esophagus contains only smooth muscle in the distal two-thirds; it can be used to study autonomic control of esophageal smooth muscle. Three different preparations of opossum esophagus were used; the esophagus in vivo, the isolated whole esophagus, and isolated strips of the three layers of esophageal smooth muscle. Responses were examined to localized distension and to electrical s...

Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro. Here we studied IGF-I and IGFBP-5 in Crohn's disease tissue. Tissue was collected from pati...

This study was carried out to gather species-specific data on mast-cell density and distribution in camel small intestine under different fixation conditions and to elucidate the presence and cross-reactivity of tryptase in the camel small intestine using human specific anti-tryptase antibody. Tissue specimens from the jejunum, duodenum, and ileum were obtained from 9 healthy, 9-12 months old, ...

Much has been writ’tcn about the motor activities of the intestinal tract. A survey of the literature shows that with a few exceptions these writings have been based upon experiments and observations involving only the outer, the circular and longitudinal muscles of the intestine. Little attention has been given to the activities of the muscularis mucosae. Inasmuch as in all higher animals this...