The potential of the cross-section (CS) approach in combination with the partial least squares (PLS) and principal component regression (PCR) was assessed in the resolution of a complex pesticide mixture showing twelve overlapped components in High Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD). Careful selection of the CS through the three-dimensional (3D) (A, lambda, ...

The multivariate calibration problem deals with inference concerning an unknown value of a covariate vector based on observation response vector. Two distinct scenarios are considered in the problem: controlled where covariates non-stochastic, and random random. Under calibration, interest is computation confidence region for that computing prediction Assuming standard normal linear regression ...

Second-order calibration and multivariate spectroscopic-kinetic measurements in the visible region are proposed to improve the Jaffé method for creatinine assay. Analyses performed on synthetic mixtures containing bilirubin, glucose, and albumin confirm that second-order calibration is useful for creatinine determination in human serum. Quantitative determinations of creatinine with the paralle...

Model calibration entails the inference about unobservable modeling parameters based on experimental observations of system response. When the model being calibrated is an expensive computer simulation, special techniques such as surrogate modeling and Bayesian inference are often fruitful. In this work we show how the flexibility of the Bayesian calibration approach can be exploited in order t...

BACKGROUND Metronidazole (MET) and Diloxanide Furoate (DF), act as antiprotozoal drugs, in their ternary mixtures with Mebeverine HCl (MEH), an effective antispasmodic drug. This work concerns with the development and validation of two simple, specific and cost effective methods mainly for simultaneous determination of the proposed ternary mixture. In addition, the developed multivariate calibr...