Some protein design tasks cannot be modeled by the traditional single state design strategy of finding a sequence that is optimal for a single fixed backbone. Such cases require multistate design, where a single sequence is threaded onto multiple backbones (states) and evaluated for its strengths and weaknesses on each backbone. For example, to design a protein that can switch between two speci...

Abstract All currently known exactly solvable multistate Landau–Zener (MLZ) models are associated with families of operators that commute the MLZ Hamiltonians and depend on time linearly. There can also be satisfy integrability conditions but quadratically. We show that, among systems, such time-quadratic much more common. demonstrate then generally lead to constraints independent variables par...

Most of the methods that have been developed for computational protein design involve the selection of side-chain conformations in the context of a single, fixed main-chain structure. In contrast, multistate design (MSD) methods allow sequence selection to be driven by the energetic contributions of multiple structural or chemical states simultaneously. This methodology is expected to be useful...

We present results for fB and masses of low-lying heavy-light mesons. Calculations were performed in the quenched approximation using multistate smearing functions generated from a spinless relativistic quark model Hamiltonian. Beta values range from 5.7 to 6.3, and light quark masses corresponding to pion masses as low as 300 MeV are computed at each value. We use the 1P{1S charmonium splittin...