An autosomal recessive juvenile-onset form of Parkinson's disease (AR-JP) is caused by loss-of-function mutations of the parkin gene, which encodes a ubiquitin-protein ligase. Three recent reports demonstrate that parkin can protect neurons from diverse cellular insults, including alpha-synuclein toxicity, proteasomal dysfunction, Pael-R accumulation, and kainate-induced excitotoxicity. These f...

1Laboratory of Microbial Ecology and Technology (LabMET), University of Ghent, 9000 Ghent, Belgium 2Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna, 40131 Bologna, Italy 3Department of Chemistry, UCBIO-Requimte, Faculty of Science&Technology, NewUniversity of Lisbon, 2829-516 Caparica, Portugal 4Laboratory of Biochemical Engineering and Envi...

The paper presents LinkGen, a synthetic linked data generator that can generate a large amount of RDF data based on certain statistical distribution. Data generation is platform independent, supports streaming mode and produces output in N-Triples and N-Quad format. Different sets of output can be generated using various configuration parameters and the outputs are reproducible. Unlike existing...

Black phosphorus (BP) has recently emerged as a promising semiconducting two-dimensional material. However, its viability is threatened by its instability in ambient conditions and by the significant decrease of its band gap in multilayers. We show that one could solve all the aforementioned problems by interfacing BP with hexagonal boron nitride (hBN). To this end, we simulate large, rotated h...

This paper explores the impact of various group decision-making approaches on the performance of a multipurpose reservoir. The reservoir operation problem is solved by a continuous flexible stochastic dynamic program (FSDP) in which the variability and temporal persistence of the inflows are apprehended by a Markov model. Operating objectives are encoded as fuzzy sets whose membership functions...

PURPOSE Lens case hygiene is important for safe contact lens wear. However, there are no evidence-based data to suggest optimum hygiene regimens. This in vitro study aimed to evaluate and compare the effectiveness of manufacturers' guidelines and several other regimens in removing biofilm using various types of contact lens cases and disinfecting agents. METHODS Biofilms of Staphylococcus aur...

Background A multipurpose health worker (MPHW) is the key functionary and the first contact person in a subcenter. This study explores the workload of MPHWs in the multifarious domains of their activities and also assesses their time utilization pattern. Methods A time and motion study was conducted among 19 auxiliary nurse midwives (ANMs) and 10 HWs male (M) from six selected primary health ...

Multipurpose hydropower reservoirs are regularly framed as water security and climate change solutions. Although multipurpose projects can do deliver a range of services, ‘win-win’ outcomes not guaranteed. Emerging energy risks altering the net benefits from operating to generation, supply, flood control, or other purposes. This paper shows that new governance approaches needed efficiently fair...

Webjspell is an Internet multipurpose tool for Portuguese morphological analysis and spell checking. It provides examples of phrases, frequencies, verbal conjugation tables, word suggestions, and Internet pages spell checking. This article describes Webjspell features, and results.

Spatial and mobile computing evolves. This paper describes a smart modeling platform called “GeoSEMA”. This approach tends to model multidimensional GeoSpatial Evolutionary and Mobile Agents. Instead of 3D and location-based issues, there are some other dimensions that may characterize spatial agents, e.g. discrete-continuous time, agent behaviors. GeoSEMA is seen as a devoted design pattern mo...