Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1 in the liver after birth is no longer leth...

The metal-regulatory transcription factor 1 (MTF-1) is a key regulator of heavy metal-induced transcription of metallothionein I and II and other genes in mammals and other metazoans. Transcriptional activation of genes by MTF-1 is mediated through binding to metal-responsive elements of consensus TGCRCNC in the target gene promoters. In an attempt to further clarify the mechanisms by which cer...

Mitochondrial ferritin (MtF) is structurally and functionally similar to the cytosolic ferritins, molecules designed to store and detoxify cellular iron. MtF expression in human and mouse is restricted to the testis and few tissues, and it is abundant in the erythroblasts of patients with sideroblastic anemia, where it is thought to protect the mitochondria from the damage caused by iron loadin...

Mitochondrial ferritin (MtF) is structurally and functionally similar to the cytosolic ferritins, molecules designed to store and detoxify cellular iron. MtF expression in human and mouse is restricted to the testis and few tissues, and it is abundant in the erythroblasts of patients with sideroblastic anemia, where it is thought to protect the mitochondria from the damage caused by iron loadin...

Background: Metal-responsive transcription factor-1 (MTF-1) is a key transcriptional regulator playing crucial roles in metal homeostasis and cellular adaptation to diverse oxidative stresses. In order to understand cellular pathways associated with metal regulation and stress responses in Pacific abalone (Haliotis discus hannai), this study was aimed to isolate the genetic determinant of abalo...

The purpose of this research is to achieve uniform spatial resolution in CT (computed tomography) images without hardware modification. The main idea of this study is to consider geometry optics model, which can provide the approximate blurring PSF (point spread function) kernel, which varies according to the distance from X-ray tube to each pixel. The FOV (field of view) was divided into sever...

The aim of this study was to investigate the hypolipidemic effect of the total flavonoids from mulberry leaves (MTF) in hyperlipidemic mice. The total flavonoids have been isolated from mulberry (Morus alba L.) leaves and purified by macroporous resins. After that, the content of MTF is 581.7 mg g-1 in dried product. The hypolipidemic effect of MTF has been evaluated in triton WR-1339 (400 mg k...

Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein that activates transcription in response to heavy metals such as Zn(II), Cd(II) and Cu(I) and is also involved in the response to hypoxia and oxidative stress. MTF-1 recognizes a specific DNA sequence motif termed the metal response element (MRE), located in the promoter/enhancer region of its target genes. The functional ...

Inspired by recent successes of deep learning in computer vision and speech recognition, we propose a novel framework to encode time series data as different types of images, namely, Gramian Angular Fields (GAF) and Markov Transition Fields (MTF). This enables the use of techniques from computer vision for classification. Using a polar coordinate system, GAF images are represented as a Gramian ...

We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1 die in utero at approximately day 14 of gestation. They show impaired development of hepatocytes an...