Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.

The central nervous system (CNS) of patients with multiple sclerosis (MS) is the site where disease pathology is evident. Damaged CNS tissue is commonly associated with immune cell infiltration. This infiltrate often includes B cells that are found in multiple locations throughout the CNS, including the cerebrospinal fluid (CSF), parenchyma, and the meninges, frequently forming tertiary lymphoi...

the protective capacity of the crude extracts from larval and nymphal stages of hyalomma anatolicum anatolicum was examined in the new zealand white rabbits. the rabbits were randomly divided into 3 groups of five animals. the rabbits in groups 1 and 2 were immunized with crude extracts of larval and nymphal antigens, respectively and group 3 was served as control. following challenge of each r...

A glycoprotein of 25,000 daltons was isolated from a human T lymphoblastoid cell line (MOLT-3). A monovalent antiserum raised against this antigen precipitated mouse Thy-1.1 antigen as well as a 25,000-dalton antigen from human blood T cells. The unabsorbed serum was also cytotoxic for both mouse and human T cells. By multiple criteria, this human T antigen appears to be homologous with mouse T...

Abstract Genetic engineering of T-cells using chimeric antigen receptors (CARs) has shown promise in the treatment relapsed/refractory B-cell leukemia. However, a significant percentage patients will eventually relapse, often due to emergence tumor cells expressing low levels target antigen. Previous research demonstrated that hinge domain CAR plays crucial role regulating cytotoxic capabilitie...

Most Escherichia coli O157-serogroup strains are classified as enterohemorrhagic E. coli (EHEC), which is known as an important food-borne pathogen for humans. They usually produce Shiga toxin (Stx) 1 and/or Stx2, and express H7-flagella antigen (or nonmotile). However, O157 strains that do not produce Stxs and express H antigens different from H7 are sometimes isolated from clinical and other ...

Merkel cell carcinoma (MCC) is a rare and aggressive cancer of the skin with ∼30% mortality. Around 80% MCC tumors originate from integration polyomavirus (MCPyV) DNA into host genome, leading to expression viral T-antigen oncoprotein ultimately, tumorigenesis. Though PD-1 pathway blockade has significantly improved outcomes for advanced MCC, many patients do not benefit or develop resistance t...

Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promis-ing approach in immunotherapy of cancer. It has been demonstrated that Listeria mono-cytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a consider-able anti tumor immunity. Objective: The present study w...

Background: Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein ...