This study was designed to confirm the previously observed favorable survival rates and prognostic factors in young children with nonmetastatic medulloblastoma (MB) treated with postoperative chemotherapy alone. Patients who received a diagnosis during the period January 2001 through December 2005 and who were aged <4 years received 3 cycles of postoperative systemic multiagent chemotherapy and...

Multiagent techniques improves student learning in ComputerSupported Collaborative Learning (CSCL) environments through multiagent coalition formation and intelligent support to the instructors and students. Researchers designing the multiagent tools and techniques for CSCL environments are often faced with high cost, time, and effort required to investigate the effectiveness of their tools and...

Five years of application-driven research taught us that there is a close connection between multiagent systems and software architecture. In this paper, we give an overview of a reference architecture for situated multiagent systems we have developed during our research. The reference architecture generalizes common functions and structures from various applications we have studied and built. ...

We consider a multiagent extension of single-agent graph coloring. Multiple agents hold disjoint autonomous subgraphs of a global graph, and every color used by the agents in coloring the graph has associated cost. In this multiagent graph coloring scenario, we seek a minimum legal coloring of the global graph’s vertices, such that the coloring is also Pareto efficient, socially fair, and indiv...

Current practice in multiagent systems typically associates the environment with resources external to the agents and infrastructure for communication. Advanced uses of the environment are infrastructures for indirect coordination such as digital pheromones, or support for governed interaction as in electronic institutions. Yet, in general, the notion of environment is not well defined. Functio...

As agent technology acceptance grows, there is a need for software engineering approaches to deal with the design of large, complex multiagent applications. Currently, existing approaches work well for small systems but are not well suited for large, complex applications. Thus, we propose extending multiagent approaches with service-oriented principles to simplify the design of such systems. Ou...

Multiagent systems are well suited to specify requirements for open physical complex systems. However, up to now, no method allows to build software/hardware hybrid multiagent systems. This paper presents an original method for designing physical multiagent systems.

Numerous systemic treatment options exist for patients with mycosis fungoides (MF) and Sézary syndrome (SS), but no large comparative studies are published. To study the efficacy of treatments, a retrospective analysis of our cutaneous lymphoma database was undertaken, with 198 MF/SS patients undergoing systemic therapies. The primary end point was time to next treatment (TTNT). Patients with a...

Osteosarcoma is the most common primary malignant tumor of bone. The disease, however, is very rare with less than 2,000 expected patients at all age groups per year within the European Union and the United States of America. With multimodal therapy, which combines multiagent chemotherapy and complete resection of all macroscopically detectable tumors, about 60%-70% of patients with localized o...