In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation-contraction, coronary blood flow and ven...

this paper addresses a multi-criteria decision based methodology to develop a road network cost function for route finding analysis in a geographic information system (gis). over the years, several studies relating to route planning process in gis and intelligent transportation systems (its) have been conducted, most of which rely on the use of one-dimensional variables like distance or time as...

The accurate simulation of the dynamics of polydisperse evaporating sprays in unsteady gaseous flows with large-scale vortical structures is both a crucial issue for industrial applications and a challenge for modeling and scientific computing. The difficulties encountered by the usual Lagrangian approaches make the use of Eulerian models attractive, aiming at a lower cost and an easier couplin...

Ever since the raft model for biomembranes has been proposed, the traditional view of biomembranes based on the fluid-mosaic model has been altered. In the raft model, dynamical heterogeneities in multi-component lipid bilayers play an essential role. Focusing on the lateral phase separation of biomembranes and vesicles, we review some of the most relevant research conducted over the last decad...

The accurate simulation of the dynamics of polydisperse evaporating sprays in unsteady gaseous flows with large scale vortical structures is both a crucial issue for industrial applications and a challenge for modeling and scientific computing. The difficulties encountered by the usual Lagrangian approaches make the use of Eulerian models attractive, aiming at a lower cost and an easier couplin...

In this paper, a numerical study is conducted in order to compare hyperbolic range of equations of isotherm two-fluid model governing on two-phase flow inside of pipe using conservative Shock capturing method. Differential equations of the two-fluid model are presented in two forms (i.e. form I and form II). In forms I and II, pressure correction terms are hydrodynamic and hydrostatic, respecti...

Multi-fluid models have recently been proposed as an approach to improving the representation of convection in weather and climate models. This is attractive framework it fundamentally dynamical, removing some assumptions mass-flux schemes which are invalid at current model resolutions. However, still not understood how best close multi-fluid equations for atmospheric convection. In this paper ...