نتایج جستجو برای: mucoadhesive tablet

تعداد نتایج: 34063  

2013
Ankit Anand Kharia Akhlesh Kumar Singhai

The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. Nanoparticulate formu...

2012
Amit Kumar Nayak Dilipkumar Pal

The work investigates the development and optimization of ionotropically-gelled mucoadhesive beads composed of tamarind seed polysaccharide (TSP)-alginate polymer-blend for oral delivery of metformin HCl using 32 factorial design. The optimized mucoadhesive beads exhibited 94.86 ± 3.92 % drug encapsulation efficiency and good mucoadhesivity with the biological membrane in wash-off test, and sus...

2013
KK Muraleedhara SK Senthil Kumar S Parthiban

Mucoadhesive delivery systems offer several advantages over other oral controlled release systems by virtue of prolongation of residence time of drug, its targeting, and localization of the dosage form at a specific site. These advantages include bypass of first pass metabolism of the drug and hence more concentration of the drug is available for absorption. Mucoadhesion occurs between two surf...

HR Patel MM Patel

The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing aceclofenac. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelli...

Journal: :iranian journal of pharmaceutical research 0
fatemeh khonsari student research committee, tabriz university of medical sciences, tabriz, iran. parvin zaker-milani 1- faculty of pharmacy, tabriz university of medical sciences, tabriz, iran. 2- liver and gastrointestinal diseases research center, tabriz university of medical sciences, tabriz, iran. mitra jelvehgari 1- faculty of pharmacy, tabriz university of medical sciences, tabriz, iran. 2- drug applied research center, tabriz university of medical sciences, tabriz, iran.

the present study involves preparation and evaluation of gastric-mucoadhesive microparticles with metformin hydrochloride as model drug for prolongation of gastric residence time. the microparticles were prepared by the emulsification solvent evaporation technique using polymers of carbomer 934p (c) and ethylcellulose (ec). the microparticles were prepared by emulsion solvent evaporation method...

D Patel J Patel J Raval

The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...

2012
A. A. Shaikh Y. D. Pawar S. T. Kumbhar Amir A. Shaikh

This study describes the effect of Guar gum and chitosan on formulation of mucoadhesive drug delivery system of itraconazole. Mucoadhesive strength, Drug content, Hardness, Friability, Weight variation, Moisture content and accelerated stability studies were performed to study the effect of polymers on prepared mucoadhesive tablets. Results of the present study clarified the potential of guar g...

Journal: :iranian journal of pharmaceutical research 0
n mehravaran

the aim of this study was to investigate the rheological behavior and mucoadhesive nature of saliva substitutes, by incorporating various mucoadhesive polymers into an artificial saliva pump spray formulation. for this purpose various mucoadhesive polymers including cellulosic polymers in the range of 0.1-1.0% and carbomers such as c974p, c971, c934p and c971 in the range of 0.01-0.1% were adde...

Journal: :Chemical & pharmaceutical bulletin 2010
Veena Shailendra Belgamwar Sanjay Javerilal Surana

The aim of the present study was to prepare mucoadhesive multiparticulate system for oral drug delivery using ionic gelation technique. Microspheres of different mucoadhesive polymers including hydroxypropyl methylcellulose (HPMC) K15M and carbopol 971P were prepared. In this technique cross linking of sodium alginate with calcium chloride was done which retarded the release of drug from the mu...

2014
Fatemeh Khonsari Parvin Zakeri-Milani Mitra Jelvehgari

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (CP) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation metho...

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