Gout is characterized by the monosodium urate monohydrate (MSU)-induced arthritis. Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Here, we used bioinformatics, proteomics, cell models, and twenty in vitro human assays to clarify some of its role in the inflammatory response to MSU. We found myosin IIA to be a frequent interacting protein partner of ALP...

INTRODUCTION Gout is characterized by episodes of intense joint inflammation in response to intra-articular monosodium urate monohydrate (MSU) crystals. miR-155 is crucial for the proinflammatory activation of human myeloid cells and antigen-driven inflammatory arthritis. The functional role of miR-155 in acute gouty arthritis has not been defined. Therefore, the aim of this study was to examin...

OBJECTIVES To investigate the effects and mechanisms of action of high-density lipoproteins (HDL) in monosodium urate (MSU) crystal-induced inflammation -that is, gouty inflammation, in vivo. METHODS Air pouches raised on the backs of mice were injected with MSU crystals or tumour necrosis factor (TNF) in the presence or absence of HDL and/or interleukin (IL)-1 receptor antagonist (IL-1Ra) fo...

We present moderate resolution spectroscopy of 112 cool dwarf stars to supplement the observations we have already presented in the Palomar/MSU Nearby-Star Spectroscopic Survey. The sample consists of 72 suspected nearby stars added to the The Preliminary Third Catalog of Nearby Stars since 1991 as well as 40 faint red stars selected from the LHS catalog. LHS 1826 is more metal-poor and cooler ...

Satellite-based layer average stratospheric temperature (T) climate data records (CDRs) now span more than three decades and so can elucidate climate variability associated with processes on multiple time scales. We intercompare and analyze available published T CDRs covering at least two decades, with a focus on Stratospheric Sounding Unit (SSU) and Microwave Sounding Unit (MSU) CDRs. Recent r...

We construct modular invariants on MSU(2), the moduli space of quantum vacua of N = 2 SYM with gauge group SU(2). We also introduce the nonchiral function K(A, Ā) = 2απeSW, where eSW is the Seiberg–Witten metric, e is the Poincaré metric on MSU(2) and α is a regularization scheme–dependent constant. It turns out that K(A, Ā) has all the expected properties of the next to leading term in the Wil...

Welcome to Michigan State University. It is our hope that your life at MSU will be fulfilling and successful, now and in the future. To enable you to begin the process of learning the lay of the land at MSU, we have created this orientation website designed specifically for new Fixed Term Faculty. We invite you to explore this website carefully. It provides information on relevant orientation e...

Michigan State University Quality Matters: Teaching Tools MSU has a campus subscription to QM. This page provides information for creating a personal QM account in order to make full use of the QM rubric and online resources to create and assess improved online education and student learning. Also offers links to other technology tools for teaching available at MSU. https://tech.msu.edu/teachin...

Monosodium urate (MSU), calcium pyrophosphate dihydrate (CPPD) and basic calcium phosphate (BCP) crystals deposit in joints and surrounding tissues causing acute inflammation and chronic cartilage damage. A number of endogenous substances and physicochemical conditions affect their precipitation, growth and even dissolution, regulating their metabolism and inflammatory activity. We review how M...