Vitamin D deficiency has been implicated as a risk factor for multiple sclerosis (MS), but how vitamin D metabolism affects MS pathophysiology is not understood. We studied the expression of vitamin D receptor (VDR) and related enzymes, including 1,25(OH)(2)D-24-hydroxylase (24-OHase; CYP24A1) and 25(OH)D-1α-hydroxylase (CYP27B1), in CNS tissues of 39 MS patients and 20 controls and in primary ...

Background and Objective We previously reported that the prevalence of MS in Tokachi Province of Hokkaido has increased from 8.6 to 13.1 per 100,000 individuals between 2001 and 2006. Here, we studied the frequency of MS patients who fulfill the Barkhof criteria and identified their common features. Subjects All 47 subjects in our previous study, who fulfilled Poser’s criteria, were included in...

We previously reported that the prevalence of multiple sclerosis (MS) in the Tokachi Province of Hokkaido increased from 8.6 to 13.1 per 100,000 individuals between 2001 and 2006. Here, we study the frequency of MS patients who fulfill the Barkhof criteria and identified their common features. All 47 subjects in our previous study, who fulfilled Poser's criteria, were included in this study. Of...

background: magnetic resonance imaging (mri) has improved the diagnosis and management of patients with multiple sclerosis (ms). montreal cognitive assessment (moca) is a brief, sensitive test that has been recommended by national institute of neurological diseases and stroke and canadian stroke network (ninds-csn) as a reliable tool to detect mild cognitive impairments. this study aimed to eva...

Segmenting of Multiple Sclerosis (MS) lesions in magnetic resonance (MR) images is a hot issue in biomedical engineering. This paper presents a novel approach for segmentation of MS lesions in T1weighted (T1-w), T2-weighted (T2-w), and fluid-attenuated inversion recovery (Flair) MR images. The proposed approach is based on threedimensional (3D) enhancement followed by false positive reduction m...

OBJECTIVE To study the clinical and radiological characteristics of multiple sclerosis (MS) with onset below 18 years. METHODS This retrospective study was carried out at the MS Clinic in the Medical City Hospital in Baghdad, Iraq between March 2008 and March 2009. The records of the center were surveyed, and 77 patients with the onset of MS below 18 years were identified. Their clinical and ...

BACKGROUND AND PURPOSE Improving the sensitivity of MR imaging for the detection of multiple sclerosis (MS) lesions in the cord might be useful in the diagnostic workup and could lead to a better understanding of the evolution of the disease. The purpose of this study was to compare fast spin-echo (FSE) with magnetization transfer-prepared gradient-echo (MT-GE) and fast short-inversion-time inv...

normal 0 false false false en-us x-none ar-sa background: to evaluate seizure characteristic among multiple sclerosis patients with coexistent seizure activity compared to control group. materials and methods: this study is a cross-sectional study which was conducted by reviewing the clinical records of patients with definite diagnosis of ms according to mcdonald’s criteria from march 2007 to j...

INTRODUCTION The important protective role of small heat-shock proteins (HSPs) in regulating cellular survival and migration, counteracting protein aggregation, preventing apoptosis, and regulating inflammation in the central nervous system is now well-recognized. Yet, their role in the neuroinflammatory disorder multiple sclerosis (MS) is largely undocumented. With the exception of alpha B-cry...

BACKGROUND AND OBJECTIVES While the literature supports the idea that multiple sclerosis (MS) and migraine are related, the exact mechanism(s) of this association is not well understood. Observations of increased contrast enhancing (CE) lesion activity in individual MS patients suffering from migraine prompted us to determine a relationship between migraine and MRI outcomes in a large cohort of...