We present the design and performance of a new compact preclinical system combining positron emission tomography (PET) magnetic resonance imaging (MRI) for simultaneous scans. The PET contains sixteen SiPM-based detector heads arranged in two octagons covers an axial field view (FOV) 102.5 mm. Depth interaction effects detector's temperature variations are compensated by system. is integrated d...

Introduction: While several atlases are available depicting the spatial distribution of various parameters either measured with MRI or from histological section, no comparable comprehensive data exists for the distribution of vessels in the rat brain. Angiography is able to use the blood flow in the brain of the living rat to display the largest arteries, while SWI can visualize veins down to m...

Introduction: Glioblastoma multiform is the most common malignant brain tumor, with an invasive nature. Despite the development of conventional therapies such as surgery, radiotherapy and chemotherapy, because of high recurrence rates, the prognosis remains very poor. Over the last decade, nanotechnology has represented an innovative method as nanoparticle-based drug delivery ...

PURPOSE To test the hypotheses that, in the newborn rat model of retinopathy of prematurity (ROP), the hyaloidal circulation is functionally impaired and its development is not well coordinated with that of other ocular structures. METHODS The functional response of the hyaloidal circulation to a carbogen inhalation challenge was noninvasively evaluated using magnetic resonance imaging (MRI) ...

Introduction. There is still a great interest to develop volume coils for small-animal MRI. A transceiver volume coil with slotted end-rings and similar to the standard birdcage is proposed in this work. This coil design resembles Mansfield ́s cavity resonator [1]. Unlike the traditional birdcage coil, our coil design was formed with two slotted surface coils [2] connected via rungs like the tra...

Parkinson's disease (PD) is characterized by pathological changes within several deep structures of the brain, including the substantia nigra and caudate nucleus. However, changes in interstitial fluid (ISF) flow and the microstructure of the interstitial space (ISS) in the caudate nucleus in PD have not been reported. In this study, we used tracer-based magnetic resonance imaging (MRI) to quan...

Atthe BK, Babsky AM, Hopewell PN, Phillips CL, Molitoris BA, Bansal N. Early monitoring of acute tubular necrosis in the rat kidney by Na-MRI. Am J Physiol Renal Physiol 297: F1288–F1298, 2009. First published September 2, 2009; doi:10.1152/ajprenal.00388.2009.— Reabsorption of water and other molecules is dependent on the corticomedullary sodium concentration gradient in the kidney. During the...