Mn(III) porphyrins have great potential as Gd-free MRI contrast agents because both the cation and ligand interesting properties. The redox properties of Mn(III)-ion can be exploited for preparation reactive oxygen species therapy. Moreover, porphyrin allows these complexes to a high affinity tumor tissues. inherent ligands make systems attractive photothermal, photodynamic, sonodynamic therapi...

objective(s): this study describes the preparation, biodistribution of 153sm-dtpa-spion after intravenous injection in rats. materials and methods: the chelator dtpa dianhydride was conjugated to spion using a small modification of the well-known cyclic anhydride method. conjugation was done at a 1: 4 (spion: ccdtpa) molar ratio. conjugation reaction was purified with magnetic assorting column ...