In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and vitro biological activity the NP-PUs were systematically evaluated terms AgFeO2@PEG (NP) addition segment content. High-angle ...

DDX3X, a helicase, can interact directly with mRNA and translation initiation factors, ΤΓΙΩΝΧςΚΠΙ ςθΓ ΥΓΝΓΕςΚΞΓ ςΤΧΠΥΝΧςΚΘΠ ΘΗ Ο40#Υ ςθΧς ΕΘΠςΧΚΠ Χ ΥςΤΩΕςΩΤΓΦ ƍ ΩΠςΤΧΠΥΝΧςΓΦ ΤΓΙΚΘΠ ∝764 6θΚΥ ΧΕςΚΞΚς[ ΟΘΦΩΝΧςΓΥ ςθΓ ΓΖΡΤΓΥΥΚΘΠ ΘΗ Ο40#Υ ΕΘΠςΤΘΝΝΚΠΙ cell cycle progression and mRNAs regulating actin dynamics, contributing to cell adhesion and motility. Previously, we have shown that ribosomes and tr...

Abstract Background Peri-implant mucositis and peri-implantitis are biofilm-related diseases causing major concern in oral implantology, requiring complex anti-infective procedures or implant removal. Microbial biosurfactants emerged as new anti-biofilm agents for coating implantable devices preserving biocompatibility. This study aimed to assess the efficacy of rhamnolipid biosurfactant R89 (R...

The formation of lumens in epithelial tissues requires apical-basal polarization of cells, and the co-ordination of this individual polarity collectively around a contiguous lumen. Signals from the Extracellular Matrix (ECM) instruct epithelia as to the orientation of where basal, and thus consequently apical, surfaces should be formed. We report that this pathway is normally absent in Calu-3 h...

A synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (TNF-alpha), interferons (IFN-alpha, IFN-beta, and IFN-gamma) and heat-stress was demonstrated in vitro. The toxicity of these agents was assessed in the human cervical carcinoma HeLa cell line: the toxic effect was greatly increased when cells pretreated with IFNs or TNF were submitted to a 1-h heat-shoc...

KRAS mutations are a major cause of drug resistance to molecular-targeted therapies. Aberrant epidermal growth factor receptor (EGFR) signaling may cause dysregulation of microRNA (miRNA) and gene regulatory networks, which leads to cancer initiation and progression. To address the functional relevance of miRNAs in mutant KRAS cancers, we transfected exogenous KRAS(G12V) into human embryonic ki...

This study aimed to evaluate the chemical composition of the essential oils from three genotypes of Lippia gracilis Schauer (Verbenaceae) and investigate the cytotoxic activities of these oils. Essential oils were extracted from the leaves using a Clevenger-type apparatus, and chemical analysis was performed using a gas chromatograph coupled to a mass spectrometer and flame ionization detector....

Kin17 is an evolutionarily conserved DNA-binding protein, which forms intranuclear foci in proliferating cells. Recent data have suggested that human kin17 protein is associated with cell proliferation and unrepaired DNA lesions. Herein, we show that human fibroblasts (MRC5-V2 and CHSV4) immortalized with SV40 overexpress endogenous kin17 protein, as compared with normal diploid human fibroblas...

The dimorphic fungi Paracoccidioides spp. are the etiological agents of paracoccidioidomycosis (PCM), a mycosis of high incidence in Brazil. The toxicity of drug treatment and the emergence of resistant organisms have led to research for new candidates for drugs. In this study, we demonstrate that the natural product argentilactone was not cytotoxic or genotoxic to MRC5 cells at the IC50 concen...