Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific phy...

Microplastic (MP) pollution is an emerging environmental issue. While it evident that human activities are the primary source of MP pollution, relationship between land use and in rivers requires further study. Using data from 26 monitoring sites Chongqing section Yangtze River, we analyzed along with construction data. We improved model for Land Use Intensity Composite Index (LUI) to obtain co...

AIM Combination treatment consisting of surgery and pre-or post-operative corticosteroids for chronic subdural hematoma (CSH) tend to have better outcomes than surgery only. However, there are many complications after long-term use of corticosteroids. In this study, we evaluated the clinical outcomes of local application of corticosteroids combined with surgery for CSH. MATERIAL AND METHODS W...

BACKGROUND Chronic neutrophilic leukaemia (CNL) is a rare myeloproliferative disorder of elderly patients characterised by sustained neutrophilia and splenomegaly. The diagnosis of CNL requires the exclusion of BCR/ABL positive chronic myelogenous leukaemia (CML) and of leukaemoid reactions (LRs). The differentiation between CNL and LR is problematic because both conditions share similar morpho...

OBJECTIVE The goals of the present study were to estimate the incidence and course of full and partial Post-Traumatic Stress Disorder (PTSD) following childbirth and to prospectively identify factors associated with the development of PTSD symptoms at 1month following childbirth. METHODS The sample comprised 308 women, with assessments at four time points: 25-40weeks gestation, 4-6weeks postp...

Myofascial pain syndrome (MPS) is a form of myalgia that is characterized by local regions of muscle hardness that are tender and that cause pain to be felt at a distance, i.e., referred pain. The central component of the syndrome is the trigger point that is composed of a tender, taut band. Stimulation of the band, either mechanically or with activity, can produce pain. The active trigger poin...

By using the Double Frontiers Criteria, Hurwicz succeeded to achieve The Most Productive Scale Size of decision making units. This Double frontiers criteria was achieved by using two models of “CCR” in optimistic viewpoint in input form and the “CCR” model in pessimistic viewpoint in input form. In this paper, we intend to find a criteria for Double frontiers of super efficiency by using two mo...

The beet armyworm (Spodoptera exigua) and the rice water weevil (Lissorhoptrus oryzophilus) are two important insect pests in rice production. To identify insect-responsive genes in rice, we performed a deep transcriptome analysis of Nipponbare rice leaves infested with both beet armyworm and water weevil using massively parallel signature sequencing (MPSS). Many antisense, alternative, and nov...

We have used massively parallel signature sequencing (MPSS) to sample the transcriptomes of 32 normal human tissues to an unprecedented depth, thus documenting the patterns of expression of almost 20,000 genes with high sensitivity and specificity. The data confirm the widely held belief that differences in gene expression between cell and tissue types are largely determined by transcripts deri...

The incidence of Acanthamoeba keratitis, a disease associated with contact lens wear, has been in apparent decline with the advent of multipurpose contact lens solutions. The concentrations of the biguanides chlorhexidine digluconate (CHX) and particularly polyhexamethylene biguanide (PHMB) included in multipurpose solutions (MPSs) are sublethal for amoebae. We evaluated by flow cytometry the e...