ERAS-801 is a highly CNS-penetrant small molecule (Kp, brain, mouse = 3.7 and Kp,uu, 1.2) designed to reversibly inhibit EGFR alterations observed in GBM, including amplification the EGFRvIII variant. It currently being evaluated recurrent GBM phase 1 clinical trial THUNDERBBOLT-1 (NCT05222802). also shows vitro activity against other NSCLC. Due its high CNS penetration, an exploratory vivo stu...

Teologi merupakan hal mendasar yang paling penting dalam pendidikan Kristen. Pemahaman teologi guru Kristen sebuah langkah strategis untuk meningkatkan mutu Pendidikan secara khusus dan umum. utuh bertanggungjawab seyogianya berpusat kepada Kristus lahir dari pemahaman Alkitab utuh, baik diterapkan praaktek pendidikan. Program Pelatihan diselenggarakan oleh Yayasan Transformasi Bagimu Negeri (T...

In the learning process, educators often get into trouble when students feel sleepy, bored, lazy, and lack enthusiasm so they are less active in process. The reward method is an effort to foster student motivation. research aims examine effect of rewards on students' motivation Islamic Religious Education. design used was experimental two classes, namely class X MPK as control PMS class—data co...

Whether or not the marginal product of capital (MPK) differs across countries is a question that keeps coming up in discussions of comparative economic development and patterns of capital flows. Using easily accessible macroeconomic data we find that MPKs are remarkably similar across countries. Hence, there is no prima facie support for the view that international credit frictions play a major...

Benzocycloheptapyridine tricyclic compounds with piperazine or substituted piperidine moieties extending either from the 5- or 6-position of the tricyclic bridgehead exhibited enhanced FTase activity: this resulted from favorable binding of the ligand nitrogen with the catalytic zinc found in the FTase. A single isomer at C-11 with piperazine adduct extending from the 6-position, compound 24, e...

Araştırma, müzik öğretmeni adaylarının iyi oluşlarının sahne performansları sırasında karşılaşabilecekleri kaygı düzeyine etkisini saptamak amacıyla yapılmıştır. Bu doğrultuda oluş ve performans kaygıları (MPK) incelenmiş, her iki durum arasındaki ilişki ortaya konmuştur. Araştırmaya Bursa Uludağ Üniversitesi Eğitim Fakültesi Müzik Eğitimi Ana Bilim Dalında eğitim alan (kız n=51, erkek n=35) 86...

Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control many different biological processes. In the nematode Caenorhabditis elegans, two different RTKs (LET-23/EGFR and EGL-15/FGFR) are known to stimulate LET-60/Ras and a MAPK cascade consisting of the kinases LIN-45/Raf, MEK-2/MEK and MPK-1/ERK. This Ras/MAPK cas...

Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog, ECT-2, functions through the conserved RAS/ERK MAP kinase signaling pathway in the C. elegans germline to regulate the disassembly of SC proteins...