BACKGROUND Methylphenidate (MPH) is a neural stimulant agent, which its neurochemical and behavioral effect remain unclear. Venlafaxine is a serotonin-norepinephrine reuptake inhibitor antidepressant, which was used for management of depression and anxiety. In this study, protective effects of venlafaxine on MPH induced anxiety, depression and cognition impairment were investigated. METHODS F...

This study aims to compare the resistance phenotypes conferred by various genes encoding enzymes that phosphorylate erythromycin. The mph genes were cloned into Escherichia coli AG100A susceptible to macrolides and ketolides following disruption of the AcrAB pump. An 882 bp sequence containing a premature stop codon, homologous to the three other previously described mph genes and present widel...

BACKGROUND While stimulant therapy has been shown to be effective in the treatment of attention-deficit/hyperactivity disorder (ADHD), there is less information concerning differences between alternative stimulant medications. The purpose of this study is to examine how different formulations of methylphenidate (MPH) affect treatment patterns and hospitalizations. METHODS From a large claims ...

There is a rise in the concurrent use of methylphenidate (MPH) and fluoxetine (FLX) in pediatric populations. However, the long-term neurobiological consequences of combined MPH and FLX treatment (MPH FLX) during juvenile periods are unknown. We administered saline (VEH), MPH, FLX, or MPH FLX to juvenile Sprague Dawley male rats from postnatal day 20 to 34, and assessed their reactivity to rewa...

BACKGROUND Children with attention deficit hyperactivity disorder/developmental coordination disorder (ADHD/DCD) suffer from problems associated with gross and fine motor skills. There is no effective pharmacological therapy for such patients. We aimed to assess the impact of methylphenidate (MPH) on motor performance of children with ADHD/DCD. METHODS In this double-blind placebo-controlled,...

Thousands of children receive methylphenidate (MPH; Ritalin) for attention deficit/hyperactivity disorder (ADHD), yet the long-term neurochemical consequences of MPH treatment are unknown. To mimic clinical Ritalin treatment in children, male rats were injected with MPH (5 mg/kg) or vehicle twice daily from postnatal day 7 (PND7)-PND35. At the end of administration (PND35) or in adulthood (PND1...

The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primates to quantitatively evaluate species- and age-dependent enantiomer specific pharmacokinetics of M...

Mehrdad Alemozaffar, MD Meredith M. Regan, ScD Matthew R. Cooperberg, MD, MPH John T. Wei, MD Jeff M. Michalski, MD Howard M. Sandler, MD Larry Hembroff, PhD Natalia Sadetsky, PhD Christopher S. Saigal, MD, MPH Mark S. Litwin, MD, MPH Eric Klein, MD Adam S. Kibel, MD Daniel A. Hamstra, MD Louis L. Pisters, MD Deborah A. Kuban, MD Irving D. Kaplan, MD David P. Wood, MD Jay Ciezki, MD Rodney L. D...

651. Epidemiology of Serogroup B Meningococcal Outbreaks and Interim Guidelines for the Use of an Unlicensed Serogroup B Vaccine Under a CDCSponsored IND for the Control of Outbreaks in Organizational Settings Sarah Meyer, MD, MPH; Jessica Macneil, MPH; Amy Blain, MPH; Thomas a. Clark, MD, MPH; Amanda Cohn, MD; For the Meningococcal Outbreak Work Group,; Meningitis and Vaccine Preventable Disea...

2173. Suspending Use of Contact Precautions in Patients Colonized with Methicillin-Resistant Staphylococcus aureus in a Level III Neonatal ICU and Its Effects on Rates of Transmission Tiffany Dogan, MPH, CIC; Alexandra Hayward, MPH; Sreelatha Ponnaluri-Wears, MPH, CIC; Elizabeth Lloyd, MD; Amanda Valyko, MPH, CIC and Terri Stillwell, MD; Infection Prevention and Epidemiology, Michigan Medicine,...