Colorectal cancer, a type of malignant neoplasm originating from the epithelial cells lining the colon and/or rectum, has been the third most frequent malignancy and one of the leading causes of cancer-related deaths in the US. As a bioflavonoid with high anticancer potential, quercetin (Qu) has been proved to have a prospective applicability in chemotherapy for a series of cancers. However, qu...

A new well-defined bisbenzoin group end-functionalized poly(ε-caprolactone) macrophotoinitiator (PCL-(PI)2) was synthesized by combination of ring opening polymerization (ROP) and click chemistry. The ROP of ε-CL monomer in bulk at 110 °C, by means of a hydroxyl functional initiator namely, 3-cyclohexene-1-methanol in conjunction with stannous-2-ethylhexanoate, (Sn(Oct)2), yielded a well-define...

BACKGROUND Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers ...

J Bone Joint Surg [Br] 2007;89-B:766-71. Received 16 October 2006; Accepted after revision 22 February 2007 Our aims were to map the tibial footprint of the posterior cruciate ligament (PCL) using MRI in patients undergoing PCL-preserving total knee replacement, and to document the disruption of this footprint as a result of the tibial cut. In 26 consecutive patients plain radiography and MRI o...

Poly(3-hydroxybutyrate) (PHB) has been proposed to be a potential candidate used as biomaterial. However, its poor processability, high brittleness and rigidity have limited applicability. Transesterification reactions with poly(e-caprolactone) (PCL), one of the most promising biomedical materials, emerge an attractive alternative improve mechanical properties. In this work, poly(3-hydroxybutyr...

Biocompatible nanofibers that are capable of adapting to the physiological conditions of the human body have become increasingly important for clinical applications in recent years. Electrospun fiber mats offer particular advantages due to their large surface area and their sorption/release properties. If loaded with drugs, delivery properties can be tailored to a specific release rate. This re...