BACKGROUND Although European Society of Urogenital Radiology proposed the potential of multiparametric magnetic resonance imaging (MP-MRI) as a tool in the diagnostic pathway for prostate cancer (PCa) and published a unified scoring system named Prostate Imaging Reporting and Data System (PI-RADS version 1), these still need to be validated by real-life studies. OBJECTIVE To evaluate the role...

The Max Product (MP) is a local, iterative, message passing style algorithm that has been developed for finding the maximum a posteriori (MAP) assignment of discrete probability distribution specified by a graphical model. The scope of application of MP is vast and in particular it can serve as a heuristic to solve any combinatorial optimization problem. Despite the success of MP algorithm in t...

The aim of this study was to prepare zopiclone-loaded polycaprolactone microspheres by emulsion solvent evaporation technique with different drug-to-carrier ratios {MP 1 (1:1), MP 2 (1:2), MP 3 (1:3), and MP 4 (1:4)}, characterize and evaluate the in vivo performance. The microspheres were characterized for particle size, surface morphology, drug excipient compatibility, percentage yield, drug ...

In our work we studied methylprednisolone (MP) for its effects on the permeability of cytoplasmatic membranes of neuronal populations in the rat. We used a standard model of cellular oedema induced by water intoxication, applying MP selectively into the internal carotid (ICA) after opening the blood-brain-barrier (BBB) with mannitol. The results were assessed under fluorescence microscopy in ke...

AIMS Microparticles (MP) are cell-derived fragments known to be increased in the blood of patients with acute coronary syndromes. We aimed to assess, in ST elevation myocardial infarction (STEMI), the systemic and local (in the culprit coronary artery) levels of platelet-derived MP (PMP, CD42+CD31+) and endothelial-derived MP (EMP, CD42-CD31+) and their relation to indexes of microvascular obst...

A Mathematical Model for Blood flow through a Narrow Catheterized Artery Harjeet Kumar, R.S. Chandel**, Sanjeev Kumar*** and Sanjeet Kumar *Départment of Mathematics, Lakshmi Narain College of Technology, Raisen Road, Bhopal (MP) ** Départment of Mathematics, Government Geetanjali Girls College, Bhopal, (MP) ***Institute of Basic Science, (Dr. B.R. Ambedkar University), Khandari Campus, Agra, (UP)

Repeat DC countershock reproducibly results in myocardial necrosis in dogs. In this model, myocardial technetium99m pyrophosphate (PYP) uptake correlates linearly with tissue creatine kinase depletion (r = -0.83). The effect of pretreatment with methylprednisolone (MP) was studied with PYP in 25 dogs. In myocardium damaged by countershock, 12 MP dogs had higher tissue radioactivity sample:norma...

A cold-adapted marine alkaline protease (MP, accession no. ACY25898) was produced by a marine bacterium strain, which was isolated from Yellow Sea sediment in China. Many previous researches showed that this protease had potential application as a detergent additive. It was therefore crucial to determine the tertiary structure of MP. In this study, a homology model of MP was constructed using t...

UNLABELLED Homology modeling and structural analysis of human P-glycoprotein (hP-gp) were performed with a software package the Molecular Operating Environment (MOE). A mouse P-gp (mP-gp; PDB code: 3G5U) was selected as a template for the 3D structure modeling of hP-gp. The modeled hP-gp showed significant 3D similarities at the drug biding site (DBS) to the mP-gp structure. The contact energy ...

In order to achieve higher I/O throughput and better overall system performance, it is necessary for commercial storage systems to fully exploit the increasing core counts on modern systems. At the same time, legacy systems with millions of lines of code cannot simply be rewritten for improved scalability. In this paper, we describe the evolution of the multiprocessor software architecture (MP ...