نتایج جستجو برای: motor neuron like cells

تعداد نتایج: 2095843  

Journal: :Arquivos de neuro-psiquiatria 2016
Paulo Victor Sgobbi de Souza Wladimir Bocca Vieira de Rezende Pinto Flávio Moura Rezende Acary Souza Bulle Oliveira

Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions...

Journal: :Development 2014
Brandi N Davis-Dusenbery Luis A Williams Joseph R Klim Kevin Eggan

All muscle movements, including breathing, walking, and fine motor skills rely on the function of the spinal motor neuron to transmit signals from the brain to individual muscle groups. Loss of spinal motor neuron function underlies several neurological disorders for which treatment has been hampered by the inability to obtain sufficient quantities of primary motor neurons to perform mechanisti...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Douglas A Kerr Jerònia Lladó Michael J Shamblott Nicholas J Maragakis David N Irani Thomas O Crawford Chitra Krishnan Sonny Dike John D Gearhart Jeffrey D Rothstein

We have investigated the potential of human pluripotent cells to restore function in rats paralyzed with a virus-induced motor neuronopathy. Cells derived from embryonic germ cells, termed embryoid body-derived (EBD) cells, introduced into the CSF were distributed extensively over the rostrocaudal length of the spinal cord and migrated into the spinal cord parenchyma in paralyzed, but not uninj...

AliReza Delshad, Majid Sadeghizadeh, Shahram Darabi, Taki Tiraihi,

Background: Bone marrow stromal stem cells (BMSC) are appropriate source of multipotent stem cells that are ideally suited for use in various cell-based therapies. It can be differentiated into neuronal-like cells under appropriate conditions. This study examined the effectiveness of co-stimulation of creatine and retinoic acid in increasing the differentiation of BMSC into GABAergic neuron-lik...

Journal: :Cell 2002
Hynek Wichterle Ivo Lieberam Jeffery A. Porter Thomas M. Jessell

Inductive signals and transcription factors involved in motor neuron generation have been identified, raising the question of whether these developmental insights can be used to direct stem cells to a motor neuron fate. We show that developmentally relevant signaling factors can induce mouse embryonic stem (ES) cells to differentiate into spinal progenitor cells, and subsequently into motor neu...

Journal: :Human molecular genetics 2013
Sara K Custer Adrian G Todd Natalia N Singh Elliot J Androphy

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder that stems from low levels of survival of motor neuron (SMN) protein. The processes that cause motor neurons and muscle cells to become dysfunctional are incompletely understood. We are interested in neuromuscular homeostasis and the stresses put upon that system by loss of SMN. We recently reported that α-COP, a member of th...

2016
Yi Lu Chunyan Tang Lei Zhu Jiao Li Huiting Liang Jie Zhang Renshi Xu

The recent investigation suggested that the TDP-43 protein was closely related to the motor neuron degeneration in amyotrophic lateral sclerosis (ALS), but the pathogenesis contributed to motor neuron degeneration largely remained unknown. Therefore, we detected the alteration of TDP-43 expression and distribution in the adult spinal cord of the SOD1 G93A transgenic mouse model for searching th...

Journal: :Neuro-degenerative diseases 2015
Yiyi Zhou Yi Lu Xin Fang Jie Zhang Jiao Li Shujuan Li Xia Deng Yaqing Yu Renshi Xu

The reason for regeneration in the adult spinal cord during motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains largely unknown. To this end, we studied the alteration of vimentin (a neural precursor cells marker in CNS)-containing cells (VCCs) in spinal cord during different stages of ALS used C57BL/6J G93A SOD1 transgenic mice mimicking ALS. Results showed that VCCs were ...

Journal: :Mechanisms of Development 1999
Muriel Perron Marie-Pierre Furrer Maurice Wegnez Laurent Théodore

In Xenopus, three neural-specific elav-like genes (ELGs) have been identified, elrB/Xel-1, elrC and elrD. With the aim to highlight possible differences in the regulation of these genes, we compared their expression patterns during development. We had previously shown that elrB is expressed from the early tailbud stage onwards, in both the central and peripheral nervous system. Here we show tha...

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