Human brains are characterised by considerable intersubject anatomical variability, which is of interest in both clinical practice and research. Computational morphometry of magnetic resonance images has emerged as the method of choice for studying macroscopic changes in brain structure. Magnetic resonance imaging not only allows the acquisition of images of the entire brain in vivo but also th...

Small bowel morphometry was studied in 25 subjects under the age of 70 years and 22 over the age of 70. There was no evidence of malabsorption or malnutrition in either group. Two distal duodenal endoscopic biopsy specimens were examined morphometrically. There were no significant correlations between age and areas of duodenal surface epithelium, crypts and lamina propria, heights of villi and ...

Voxel based morphometry (VBM) is widely used in the neuroimaging community to infer group differences in brain morphology. VBM is effective in quantifying group differences highly localized in space. However it is not equally effective when group differences might be based on interactions between multiple brain networks. We address this by proposing a new framework called pattern based morphome...

The intraobserver and interobserver reproducibility of computerized nuclear morphometry was determined in repeated measurements of 212 samples of invasive breast cancer. The influence of biological variation and the selection of the measurement area was also tested. Morphometrically determined mean nuclear profile area (Pearson's r 0.89, grading efficiency (GE) 0.95) and standard deviation (SD)...

The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). Hippocampal volumes are generally smaller in AD patients carrying the e4 allele compared to e4 noncarriers. Here we examined the effect of APOE e4 on hippocampal morphometry in a large imaging database-the Alzheimer's Disease Neuroimaging Initiative (ADNI). We automatically segmented an...

Ventricular enlargement is an important biomarker of Alzheimer’s disease (AD). However, ventricular surface morphometry analysis remains challenging due to its complicated and branching topological structure. Here we propose a novel ventricular surface registration algorithm based on the hyperbolic Ricci flow and geodesic curve lifting methods for ventricular shape morphometry study. Unlike pri...

OBJECTIVES This study aims to describe morphological peculiarities of maxillary and mandibular first molars in Europeans, Asians and Europeans with cleft lip and palate. MATERIAL AND METHODS Reflex microscopy was used to obtain three-dimensional morphometric landmarks from 40 models (11 Europeans and 13 Asians without cleft lip and palate, 16 Europeans with unilateral cleft lip and palate). T...

Methods. Forty-four surgically excised melanocytic lesions of the iris were histologically classified as nevus or melanoma. Morphometric analysis using a digital filar micrometer (LaSICO 1602N-10 and 5-4A) measured the mean size of the 10 largest nucleoli, and Feulgen staining and image cytometry (CAS 200 Cell Analysis Systems) analyzed the nuclear DNA ploidy in the lesions. Patient follow-up i...

Facial anthropometry plays a key role in clinical assessments, providing an accurate diagnosis for different syndromes. Clinicians working with the head and face (maxillo-facial, plastic and aesthetic surgeons; orthodontists and prosthodontists) are the mostly interested in this three-dimensional information, being able to estimate the normal and abnormal growth, planning and evaluating surgica...

The human brain is in a state of constant change and adaptation. This may be driven either by normal developmental or aging processes or by the effects of learning, training, and new occurrences in daily life. In addition to these aforementioned changes, more systematic influences such as gender, disease, and genes affect the brain’s structure. Using magnetic resonance imaging, brain changes an...