نتایج جستجو برای: morphine sensitization

تعداد نتایج: 32486  

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Suneeta Tumati Henry I Yamamura Todd W Vanderah William R Roeske Eva V Varga

Studies have shown that long-term (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-mediated pain sensitization are not fully understood. It was shown previously (J Neurosci 22:6747-6755, 2002) that sustained morphine exposu...

Journal: :Prague medical report 2012
R Slamberová A Yamamotová M Pometlová B Schutová L Hrubá K Nohejlová-Deykun E Nová E Macúchová

The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge doses...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
G Le Pen D Duterte-Boucher J Costentin

The conditioned place preference (CPP) induced by increasing doses (1.25-40 mg/kg) of cocaine or the specific dopamine uptake inhibitor GBR12783 was investigated in rats previously treated with cocaine (10 or 20 mg/kg), GBR12783 (10 mg/kg) or morphine (10 mg/kg) for 15 days. In solvent-pretreated rats, cocaine- and GBR12783-induced CPPs were biphasic, with the highest scores observed at 20 mg/k...

2017
Jian Wang Wei Xu Jiali Shao Zhenghua He Zhuofeng Ding Jiangju Huang Qulian Guo Wangyuan Zou

Morphine tolerance is a clinical challenge in pain management. Emerging evidence suggests that microRNA (miRNA) plays a regulatory role in the development of morphine tolerance. miR-219-5p (miR-219) targets calmodulin-dependent protein kinase II γ (CaMKIIγ) to activate central pain sensitization via N-methyl-D-aspartate (NMDA) receptor. Therefore, we hypothesized that miR-219-5p attenuates morp...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Joseph A Kim Kelly A Pollak Gregory O Hjelmstad Howard L Fields

Repeated exposure to drugs of abuse produces forms of experience-dependent plasticity including behavioral sensitization. Although a single exposure to many addicting substances elicits locomotor sensitization, there is little information regarding the motivational effects of such single exposures. This study demonstrates that a single cocaine exposure enhances both rewarding and aversive forms...

Abbas Haghparast, Abdolaziz Ronaghi, Mohammad Ebrahimzadeh,

Introduction: The role of midbrain reticular formation, which includes the nucleus cuneiformis (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in morphine-induced antinociception in formalin-induced pain model in rats. Methods: A total of 201 male Wistar rats weighing 260-310 g were used in...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Johanna J Bogulavsky Ann M Gregus Paul T-H Kim Alberto C S Costa Anjali M Rajadhyaksha Charles E Inturrisi

Previous reports utilizing pharmacological antagonists implicate kainate receptor (KAR) activation in the development of morphine tolerance, dependence, conditioned place preference (CPP), and locomotor sensitization, but the role of glutamate receptor (GluR) 5-containing KAR in these effects remains unclear because of limited selectivity of the inhibitors employed. Therefore, we examined respo...

Journal: :Dong wu xue yan jiu = Zoological research 2013
Yao-Dong Fan Hai-Chen Niu Tanzeel Huma Ling Li Gui-Mei Wang Li-Qi Xu He Ren Yuan-Ye Ma Hua-Lin Yu

Association between the reward caused by consuming drugs and the context in which they are consumed is essential in the formation of morphine-induced conditioned place preference (CPP). Glucocorticoid receptor (GRs) activation in different regions of the brain affects reward-based reinforcement and memory processing. A wide array of studies have demonstrated that blockage of GRs in some brain a...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Guang-Ping Xu Elisabeth Van Bockstaele Beverly Reyes Thelma Bethea Rita J Valentino

Chronic opiate use produces persistent changes in brain neurons that are expressed as adverse effects, including physical dependence and compulsive drug-seeking behavior. Dysregulation of the hypothalamic-pituitary-adrenal response to stress also occurs with chronic opiate administration and has been implicated as a contributing factor to continued substance abuse. This study provides the first...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Mani I Funez Luiz F Ferrari Djane B Duarte Daniela Sachs Fernando Q Cunha Berenice B Lorenzetti Carlos A Parada Sérgio H Ferreira

Previous work from our group showed that intrathecal (i.t.) administration of substances such as glutamate, NMDA, or PGE(2) induced sensitization of the primary nociceptive neuron (PNN hypernociception) that was inhibited by a distal intraplantar (i.pl.) injection of either morphine or dipyrone. This pharmacodynamic phenomenon is referred to in the present work as "teleantagonism". We previousl...

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