One of the most important targets in Alzheimer disease is Beta site amyloid precursor protein cleaving enzyme-1 (BACE-1). It is a membrane associated protein and is one of the main enzymes responsible for amyloid β (Aβ) production. Up to now, a considerable number of peptidic and non-peptidic inhibitors of BACE-1 have been developed. Recently, small molecule BACE-1 inhibitors have attracted the...

An anti-tumor compound as N3-{phenyl [(4-pyridylcarbonyl) amino] methyl} weresynthesized and identified (NPPA). Fe (III), Co(II) and Pd(II) metal complexes of this ligand preparedby reaction of chloride salt of Fe (III), Co(II) and Pd(II) with NPPA in dry acetonitrile. Identification andCharacterization of the ligand was performed by FT-IR, 1H-NMR spectroscopy and elemental an...

programmed cell death-1 (pd-1) and its ligands, pd-l1 and pd-l2, have been regarded as important immune system regulatory molecules. the aberrant expression of the molecules has been related to several autoimmune disorders. this study is aimed to assess the mrna expression level of pd-1, pd-l1, and pd-l2 molecules in the peripheral blood mononuclear mells (pbmcs) from multiple sclerosis (ms) pa...

here, we report the synthesis of a schiff-base mixed-ligand complex of cadmium(іі) in bulk and nano-scales via the precipitation and sonochemical methods, respectively. the complex formula is [cd(3-bpdh)(3-bpdb)cl2]n (1), where the ligands are 3-bpdh = 2,5-bis(3-pyridyl)-3,4-diaza-2,4-hexadiene and 3-bpdb = 1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene. the structure of mixed-ligand complex (1) wa...

objective(s): the aim of this study was to synthesize triangular gold nanoparticles, and then to evaluate their capability for inhibition of candida albicans secreted aspartyl proteinase 2(sap2).materials and methods: to synthesize the nanoparticles, hydrogen tetrachloroaurate and hexadecyl trimethyl ammonium bromide were incubated in presence of sn(iv) meso-tetra(n-methyl-4-pyridyl) porphine t...

Lithium trimethylsilyldiazomethanide and a cobalt (II) precursor with an N-anchored tris-NHC (TIMENmes ) ligand provide access to the nitrilimide 1. Complex 1 was structurally characterized by single-crystal X-ray diffractometry (SC-XRD) its electronic structure examined in detail, including EPR spectroscopy, SQUID magnetometry computational analyses. The desilylation of C-(trimethylsilyl)nitri...