Although this human plasma enzyme was shown (1) to have certain characteristics in common with plasma amine oxidases from other mammals (2-6), it could be distinguished from these other plasma enzymes by its substrate specificity. During studies relating to the substrate specificity of the human enzyme, the oxidation of aliphatic amines was noted to have a number of distinctive kinetic features...

A screening study focusing on monoamine oxidase inhibitory activity on the EtOAc extract of an Ascomycete Chaetomium quadrangulatum, which previously gave five unique chromones possessing this activity (chaetoquadrins A-E (1-5)), this time afforded six new constituents termed chaetoquadrins F-K (6-11) in addition to 1-5. The structures of 6-11 have been deduced on the basis of spectral and chem...

Amine oxidases that occur in the plasma of mammals have been intensively studied in recent years (l-8). The ability of human plasma and serum to convert benzylamine to benzaldehyde has recently been demonstrated (9). Evidence has been presented to show that this enzymatic activity is different from other human plasma enzymes that catalyze the oxidation of amines (i.e. ceruloplasmin and diamine ...

Monoamine oxidase of bovine kidney mitochondria has been purified to high specific activity by solubilization with digitonin, ammonium sulfate fractionation, and calcium phosphate gel-cellulose column chromatography. Absorption and fluorescence spectra indicated strongly that mitochondrial monoamine oxidase is a flavoenzyme. Under anaerobic conditions, benzylamine reduced the flavin at 460 rnp ...

The density of sympathetic nerve terminals in human superficial temporal arteries from 5 cases at intra- and extracranial bypass surgery was examined with two histochemical methods, one with potassium permanganate fixation and the other with the new monoamine oxidase staining technique. By potassium permanganate fixation, small cored vesicles containing fibers of noradrenergic nerve terminals m...

Oxidative stress plays a vital role in dopaminergic neurodegeneration of Parkinson’s disease (PD). However, an antidiabetic drug, pioglitazone had shown a positive effectagainst oxidative stress to treat nervous unrest. Objective of this study is to evaluate the protective effect of Pioglitazone (25mg/kg/p.o) against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of PD. The PD i...

The most readily available source of monoamine oxidase in man is the platelet, although only the B form of the enzyme is represented in this site. Platelet activity is higher in women than in men. The enzyme activity is generally stable and is partly under genetic control. There is some evidence that individuals with low activity have a higher psychiatric morbidity than those with high activity...