نتایج جستجو برای: modified hsa

تعداد نتایج: 254046  

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Joanna E Adrian Klaas Poelstra Gerrit L Scherphof Dirk K F Meijer Anne-miek van Loenen-Weemaes Catharina Reker-Smit Henriëtte W M Morselt Peter Zwiers Jan A A M Kamps

In the fibrotic liver, hepatic stellate cells (HSC) produce large amounts of collagen and secrete variety of mediators that promote development of fibrosis in this organ. Therefore, these cells are considered an attractive target for antifibrotic therapies. We incorporated the bioactive lipid dilinoleoylphosphatidylcholine (DLPC) into the membrane of liposomes, and then we evaluated its effect ...

Journal: :Journal of Inflammation 2021

Abstract Objective To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment. Methods IL-1? (10 ng/mL) LPS (1 ?g/mL) was used to construct cell models with A549 cells; performed better against LPS. Different concentrations of Dex were attenuate inflammation induced by IL-1?, its effect assessed via RT-PCR detect cytokine-related...

Journal: :Cancer genomics & proteomics 2006
Go Nakajima Kazuhiko Hayashi Yaguang Xi Kenji Kudo Kazumi Uchida Ken Takasaki Masakazu Yamamoto Jingfang Ju

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs (~22 nucleotides) that regulate gene expression at a post-transcriptional level via imperfect base pairing to the 3'-UTR of their target mRNAs. Previous studies from our group identified a number of deregulated miRNAs due to the loss of p53 tumor suppressor in colon cancer cell lines. To further investigate the in vivo biological signific...

2006
Yaguang Xi Andrea Formentini Minchen Chien David B. Weir James J. Russo Jingyue Ju Marko Kornmann Jingfang Ju

The functions of non-coding microRNAs (miRNAs) in tumorigenesis are just beginning to emerge. Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene. In this study, the in vivo significance of some of these miRNAs was further evaluated using colorectal clinical samples. Ten miR...

Journal: :Molecules 2018
Andrew Levitz Fahad Marmarchi Maged Henary

Heptamethine cyanine dyes are a class of near infrared fluorescence (NIRF) probes of great interest in bioanalytical and imaging applications due to their modifiability, allowing them to be tailored for particular applications. Generally, modifications at the meso-position of these dyes are achieved through Suzuki-Miyaura C-C coupling and SRN1 nucleophilic substitution of the chlorine atom at t...

2014
Shaida Moghaddassi Will Eyestone Colin E. Bishop

As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimulated homology-directed repair (HDR). Pedigreed bovine fibroblasts were co-transfected with TALENs and an 11.5-kb human serum albumin (HSA) minigen...

Journal: :European Heart Journal 2022

Abstract Introduction Vasoplegic syndrome (VS) is one of the most common unexpected complications following cardiothoracic surgery, approaching a 25% mortality rate. No standardized methods for diagnosing VS are available. A biomarker valuable tool in all fields medicine, especially cardiovascular disease when patient has to undergo invasive surgery as on-pump CABG. MicroRNAs (miRNAs) have been...

M Amir Bakhtiarvand M Rezaei Tavirani S Hesami Takallu SH Kalantari SM Mahdavi

Human serum albumin (HSA) is the most abundant plasma protein in the human body. HSA plays an important role in drug transport and metabolism. This protein has a high affinity to a very wide range of materials, including metals such as Cu2+ and Zn2+, fatty acids, amino acids and metabolites such as bilirubin and many drug compounds. In this study, we investigated the effects of co-amoxiclav, as...

2018
Ye Chen Yue-Yue Ding Yan Ren Lei Cao Qiu-Qin Xu Ling Sun Ming-Guo Xu Hai-Tao Lv

The present study used microarray analysis to screen the plasma expression of microRNAs (miRNAs) in patients with acute Kawasaki disease (KD) and aimed to explore the pathogenesis of KD. Plasma was collected from children with acute KD (n=6) and from healthy control children (n=6). Total RNA was extracted and differential miRNA expression between the two groups was determined. Differentially ex...

Journal: :Photochemistry and photobiology 1993
C Dughi N V Bhagavan D M Jameson

Familial dysalbuminemic hyperthyroxinemia (FDH) is an autosomal dominant syndrome in which clinically euthyroid patients have elevated total thyroxine levels. These high serum thyroxine levels are traceable to altered binding of thyroxine to the patient's albumin. Albumin from FDH patients and normal volunteers have been purified. Reverse-phase and ion-exchange high performance liquid chromatog...

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