objective: 8-methoxypsoralen (8-mop) is a photoactive compound widely used in the treatment of proliferate disorders. the present study investigates the effects of 8-mop on ovary function and pituitary-gonad axis in mice. materials and methods: in this experimental analytical study, 45 female balb/c mice were divided into three groups (n=15), control, sham (olive oil injection) and experimental...

Heterostructured Electrocatalysts In article number 2102413, Baocang Liu, Rui Gao, Jun Zhang, Bin and co-workers report the construction of a novel heterostructured electrocatalyst CePO4/MoP/carbon cloth (CC) constituting MoP nanobelts with surface-decorated CePO4 nanoparticles on CC for hydrogen evolution reaction (HER). The CePO4/MoP/CC exhibits low overpotential 48 mV at 10 mA cm−2 in alkali...

It is often a good idea to look at the coefficients of the polynomial from a number theoretical standpoint. The general principle is that any polynomial equation can be reduced mod m to obtain another polynomial equation whose coefficients are the residue classes mod m. Many criterions exist for testing whether a polynomial is irreducible. Unfortunately, none are powerful enough to be universal...

Activation of brain nociceptin/orphanin FQ (NOP) receptors leads to attenuation of mu-opioid receptor (MOP receptor)-mediated antinociception. Buprenorphine, a high-affinity partial MOP receptor agonist also binds to NOP receptors with 80 nM affinity. The buprenorphine-induced inverted U-shaped dose-response curve for antinociception may be due to NOP receptor activation, given that, in the pre...

BACKGROUND AND PURPOSE Data from the national joint registries in Australia and England and Wales have revealed inferior medium-term survivorship for metal-on-metal (MoM) total hip arthroplasty (THA) than for metal-on-polyethylene (MoP) THA. Based on data from the Nordic Arthroplasty Register Association (NARA), we compared the revision risk of cementless stemmed THA with MoM and MoP bearings a...

8-Methoxy psoralen (8-MOP) exerts a short-term (24 h) mitogenic action, and a long-term (48-72 h) anti-proliferative and melanogenic action on two human melanoma cell lines, SK-Mel 28 and C32TG. An increase of intracellular calcium concentration was observed by spectrofluorometry immediately after the addition of 0.1 mM 8-MOP to both cell lines, previously incubated with calcium probe fluo-3 AM...

BACKGROUND There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis. Psoralens are metabolised by cytochrome P450 enzymes (P450), and we hypothesised that variability in cutaneous P450 expression may influence PUVA sensitivity. We previously showed that P450 CYP1B1 was abundantly expressed in hu...