BACKGROUND Therapy related myeloid neoplasms (t-MNs) are complex diseases originating from an interplay between exogenous toxicities and a susceptible organism. It has been hypothesised that in a subset of cases t-MNs develop in the context of hereditary cancer predisposition syndromes. METHODS The study systematically evaluated pedigrees of patients with t-MNs for cancer incidences and the p...

Many experiments conducted in the literature have investigated the effect of microneedles (MNs) on insulin permeation across skin. There are also a number of articles that deal with the effect of MN insertion force in skin. However, there is little known on quantifying the relationship between the effect of MN insertion force and the amount of insulin permeated for given MNs. This issue is addr...

c-Jun is a transcription factor that is involved in various cellular events, including apoptotic cell death. For example, phosphorylation of c-Jun is one of the earliest biochemical changes detected in dying sympathetic neurons after NGF deprivation in vitro. However, currently, it is not known whether a similar molecular event is involved in the developmental programmed cell death (PCD) of neu...

The human mirror neuron system (MNS) is hypothesized to be crucial to social cognition. Given that key MNS-input regions such as the superior temporal sulcus are involved in biological motion processing, and mirror neuron activity in monkeys has been shown to vary with visual attention, aberrant MNS function may be partly attributable to atypical visual input. To examine the relationship betwee...

Recent research in social neuroscience proposes a link between mirror neuron system (MNS) and social cognition. The MNS has been proposed to be the neural mechanism underlying action recognition and intention understanding and more broadly social cognition. Pre-motor MNS has been suggested to modulate the motor cortex during action observation. This modulation results in an enhanced cortico-mot...

Influenza prophylaxis would benefit from a simple method to administer influenza vaccine into skin without the need for hypodermic needles. In this study, solid metal microneedle arrays (MNs) were investigated as a system for cutaneous vaccine delivery using influenza virus antigen. The MNs with 5 monument-shaped microneedles per array were produced and coated with inactivated influenza virus A...

INTRODUCTION During isometric voluntary contractions of a healthy human muscle, motoneurons (MNs) fire usually with low mean rates, rarely exceeding 25/s (e.g., Garland and Griffin, 1999). However, there are MNs, which sometimes fire double discharges (doublets) with interspike interval (ISI) of few ms. This is observed seldom in normal MNs (e.g., Denslow, 1948; Kudina, 1974; Bawa and Calancie,...

The complex inclusions of Al2O3–SiO2 is a common inclusion in the steel, which leads to stress concentration steel products. formation MnS on surface could reduce due high plasticity MnS. In this study, MnS–Al2SiO5 investigated at atomic level by using first principles calculation based density functional theory (DFT). adsorption energy atoms Mn and S Al2SiO5 (110) was calculated with various i...

High-Al steel was prepared under laboratory conditions. The single-particle AlN and multi-particle aggregated AlN, AlON, AlN–MnS, Al2O3–AlN–MnS inclusions were observed by FESEM-EDS. are mainly in the form of blocks strips, with their size concentrated range 1 to 5 μm. polygonal, toroidal, irregular shape 13 AlN–MnS is less than 15 Thermodynamic calculation shows that inclusion precipitates two...

Dysfunction in an execution/observation matching system, or mirror neuron system, has been proposed to contribute to the social deficits observed in Autism Spectrum Disorder (ASD). Atypical activity in this system, as reflected in attenuation of the EEG mu rhythm, has been demonstrated in several studies; however, normative patterns of activity have been evident in other ASD samples. The curren...