PURPOSE A major problem when using the adenoviral vectors for gene therapy applications is thought to be related to low transduction efficiency in cancer cells or to side effects in normal cells. There is an urgent requirement to improve the specificity of gene delivery in the context of cancer gene therapy. EXPERIMENTAL DESIGN We constructed a genetically modified adenovirus incorporating an...

We examine the long-term history of optical spectrum extremely variable Active Galactic Nucleus (AGN) MKN 110. By combining various archival data with new data, we cover an unprecedented long period $\sim$30 years (1987 - 2019). find that He II $\lambda 4686$ emission line changes by a factor forty and varies more strongly than continuum. Following Ferland et al. (2020), take as proxy for FUV c...

The chemokine receptor CXCR4 is associated with the biological behavior of cancer, but few studies have addressed the expression and function of CXCR4 in human gastric cancer and its impact on disease prognosis. We studied the expression of CXCR4 using RT-PCR, Western blotting, flow cytometry, and confocal microscopy in five gastric cancer cell lines. We also examined cell proliferation, migrat...

Four new (1-4), along with six known (5-10) dihydro-β-agarofuran sesquiterpene polyesters were isolated from the whole plants of Parnassia wightiana. The new compounds were structurally elucidated through spectroscopic analysis including UV (Ultraviolet Spectrum), IR (Infrared Spectrum), ¹H-NMR (¹Hydrogen-Nuclear Magnetic Resonance), ¹³C-NMR (¹³Carbon-Nuclear Magnetic Resonance), DEPT (Distorti...

We present results of a long-term variability campaign on the Seyfert 1 galaxy Markarian 110. Mkn 110 is a narrow-line Seyfert 1 object hosted in a morphological peculiar galaxy. We monitored the optical continuum and the line intensities as well as their profiles over a time interval of nearly ten years. The continuum and the Balmer lines varied by a factor of 2 to 5 within two years. The HeII...

As microtubules have a vital function in the cell cycle, oncologists have developed microtubule inhibitors capable of preventing uncontrolled cell division, as in the case of cancer. The anthelmintic drug albendazole (ABZ) has been demonstrated to inhibit hepatocellular, ovarian and prostate cancer cells via microtubule targeting. However, its activity against human gastric cancer (GC) cells ha...

We present photoionization modelling of the Extended Narrow Line Region (ENLR) in Mkn 79 based on long-slit spectra presented in our previous paper (Nazarova et al. 1996). The ENLR has been modelled with two gas components: a system of high density clouds embedded in a low density gas envelope. The ENLR line fluxes have been calculated allowing for attenuation of the nuclear ionizing continuum ...

New observations are reported of J-band spectra (1.04 μm – 1.4 μm) of three Seyfert 2 galaxies, Mkn 34, Mkn 78 and NGC 5929. In each case the spectral range includes the near-infrared lines of [Feii], [Pii], Hei and Paβ. Each Seyfert galaxy has a known radio jet, and we investigate the infrared line ratios of the nuclear and extended regions of each galaxy compared to the radio structure. In Mk...

The identification of prognostic markers and establishing their value as therapeutic targets improves therapeutic efficacy against human cancers. Ribophorin II (RPN2) has been demonstrated to be a prognostic marker of human cancer, including breast and pancreatic cancers. The present study aimed to evaluate RPN2 expression in gastric cancer and to examine the possible correlation between RPN2 e...