The Mixed Lineage Leukemia (MLL) gene is essential for embryonic hematopoietic stem cell (HSC) development, but its role during adult hematopoiesis is unknown. Using an inducible knockout model, we demonstrate that Mll is essential for the maintenance of adult HSCs and progenitors, with fatal bone marrow failure occurring within 3 weeks of Mll deletion. Mll-deficient cells are selectively lost ...

To give a proper and accurate estimation of the fatigue life of ball grid array (BGA) solder joints, a mechanical fatigue test method under mixed-mode loading is proposed. Experiments were conducted with 63Sn/37Pb and Sn/3.5Ag/0.75Cu solder joints in room temperature. The mechanical low cycle fatigue tests were performed under several loading angles. The loading angle is controlled by several g...

REPORT OF A CASE A woman in her 70s had right frontal anaplastic astrocytoma (World Health Organization grade III). The patient underwent a gross total tumor resection and a 6-week course of postoperative radiation therapy (6000 cGy) with concurrent TMZ (75 mg/m) by mouth daily. Four weeks after completion of radiation, she started adjuvant TMZ (150 mg/m by mouth), following the standard schedu...

This study explores the influence of phytoplankton on the tropical Pacific heat budget. A hybrid coupled model for the tropical Pacific that is based on a primitive equation reduced-gravity multilayer ocean model, a dynamic ocean mixed layer, an atmospheric mixed layer, and a statistical atmosphere is used. The statistical atmosphere relates deviations of the sea surface temperature from its me...

A colouring of a 4-cycle system (V,B) is a surjective mapping φ : V → Γ. The elements of Γ are colours. If |Γ| = m, we have an m-colouring of (V,B). For every B ∈ B, let φ(B) = {φ(x)|x ∈ B}. There are seven distinct colouring patterns in which a 4-cycle can be coloured: type a (××××, monochromatic), type b (×××2, two-coloured of pattern 3 + 1), type c (× × 22, two-coloured of pattern 2 + 2), ty...

this study mainly focuses on enhancing the overall efficiency of gas transmission networks. the authors developed a model with detailed characteristics of compressor and pressure reduction stations. following this, they suggested three different systems with gas turbine including: organic rankine cycle (orc), air bottoming cycle (abc), and abc along with steam injection (si-abc). in addition, u...

A new method is presented for the analysis of limit cycle oscillations in mixed-feedback systems. The calculation reformulated as zero finding a mixed-monotone relation, that is, difference two maximally monotone relations. problem can then be solved efficiently by borrowing existing algorithms minimize convex functions. potential illustrated on classical Van der Pol oscillator.

A novel topology of regulatory networks abstracted from the budding yeast cell cycle is studied by constructing a simple nonlinear model. A ternary positive feedback loop with only positive regulations is constructed with elements that activates the subsequent element in a clockwise fashion. A ternary negative feedback loop with only negative regulations is constructed with the elements that in...

In semiconductor manufacturing processes, mixed-products are usually fabricated on the same set of process tool with different recipes. Run-to-run controllers which based on the exponential weighted moving average (EWMA) statistic are probably the most frequently used in industry for the quality control of certain semiconductor manufacturing process steps. However, for mixed-product drifted pro...

BACKGROUND Abnormalities of cell cycle regulators are common features in human cancers, and several of these factors are associated with the early development of gastric cancers. However, recent studies have shown that gastric cancer tumorigenesis was characterized by mucin expression. Thus, expression patterns of cell cycle-related proteins were investigated in the early phase of differentiate...