maternal smoking has been recognized as a common cause of low birth weight, preterm birth and the decrease of gestational age period. unfortunately, there is an increasing interest within public especially woman in iran in the tobacco products consumption. on the other hand, the deleterious effect of maternal smoking on human fetus in pregnancy period especially in the first trimester encourage...

Mitochondria are essential for cell growth, fission, differentiation, and survival, particularly in undivided cells with high energy requirements, such as cardiomyocytes. The morphology position of mitochondria change the activity mitochondrial fission proteins fusion proteins. These regulatory mechanisms substantially affect cardiomyocyte supply normal function. In dynamin-related protein 1 (D...

Endoplasmic Reticulum (ER) is the largest and one of most complex cellular structures, indicating its widespread importance variety functions, including synthesis membrane secreted proteins, protein folding, calcium storage, lipid biogenesis. Moreover, ER implicated in cholesterol, plasmalogen, phospholipid, sphingomyelin biosynthesis. Furthermore, contact with organelles, such as mitochondria,...

Elaidic acid (EA) stimulation can lead to endoplasmic reticulum stress (ERS), accompanied by a large release of Ca2+, and ultimately the activation NLRP3 inflammasome in Kupffer cells (KCs). Mitochondrial instability or dysfunction may be key stimulating factors activate inflammasome, sustained Ca2+ transfer result mitochondrial dysfunction. We focused on KCs explore damag...

Mitochondria are the subcellular bioenergetic organelles. The analysis of their morphology and topology is essential to provide useful information on activity metabolism. Herein, we report a label-free shadow electrochemiluminescence (ECL) microscopy based spatial confinement ECL-emitting reactive layer image single living mitochondria deposited electrode surface. ECL mechanism freely-diffusing...

Besides skeletal muscle dysfunction, Duchenne muscular dystrophy (DMD) exhibits a progressive cardiomyopathy characterized by an impaired calcium (Ca 2+ ) homeostasis and mitochondrial dysfunction. Here we aimed to determine whether sarco-endoplasmic reticulum (SR/ER)–mitochondria interactions function were in dystrophic heart at the early stage of pathology. For this purpose, ventricular cardi...

Hypochlorite (HOCl) is one of the most important mediators inflammatory processes. Recent evidence demonstrates that changes in intracellular calcium pool play a significant role damaging effects hypochlorite and other oxidants. Mitochondria are shown to be targets hypochlorite. But little known about mitochondrial HOCl-induced dysfunction. Using isolated rat liver mitochondria, we showed oxida...

Despite recent improvements in treatment, ovarian cancer is still the leading cause of death from gynaecological malignancies. Today, marine mollusks are considered as natural source of new biologically and pharmacologically active compounds by scientists and the pharmaceutical industries. The aim of this study is to investigate the selective apoptotic effects of Turbo coronatus crude extract f...

There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical cell biological methods potential presence polymerase-1 these organelles. Our show that endogenous overexpressed poly(ADP-ribose)polymerase 1 is only localized to nucleus a clear exclusion cytosolic co...