Individuals with Lynch syndrome have a pathogenic germline variant in one of the mismatch repair (MMR) genes (MLH1, MSH2/EPCAM, MSH6, or PMS2) and are often recognized based on MMR-deficient (dMMR) colorectal cancers (CRCs) endometrial (ECs).1Lynch H.T. et al.Clin Genet. 2009; 76: 1-18Crossref PubMed Scopus (555) Google Scholar,2Kunitomi H. al.Oncol Lett. 2017; 14: 3297-3301Crossref (17) Schola...

DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision repair, mismatch repair, and recombination repair pathways. Recent studies of the fundamental mechanisms for DNA repair processes have revealed...

Postreplicative mismatch repair plays a major role in mediating the cytotoxicity of agents generating O6-methylguanine in DNA. We previously showed that a methylating antitumor triazene compound, temozolomide, induces apoptosis and that the persistence of O6-methylguanine in DNA is required to trigger the process. We wanted to test whether the latter apoptotic signal is dependent on a functiona...

The chemotherapeutic agent temozolomide produces O(6)-methylguanine (O6MG) in DNA, which triggers futile DNA mismatch repair, DNA double-strand breaks (DSB), G(2) arrest, and ultimately cell death. Because the protein complex consisting of Mre11/Rad50/Nbs1 (MRN complex) plays a key role in DNA damage detection and signaling, we asked if this complex also played a role in the cellular response t...