BACKGROUND Predicting the incidence of tuberculosis (TB) plays an important role in planning health control strategies for the future, developing intervention programs and allocating resources. OBJECTIVES The present longitudinal study estimated the incidence of tuberculosis in 2014 using Box-Jenkins methods. MATERIALS AND METHODS Monthly data of tuberculosis cases recorded in the surveilla...

This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design. Methods. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1 mg/mL). After assessment of...

Speaker diarization is necessary with ubiquitous and individualized recorders. We focus on the specific task of speaker diarization from two information streams, two microphones, assigned to two participants of interest. In real scenarios, speakers may be co-located, in noisy environments with interfering speakers. Multistream diarization can exploit additional information and diarization fusio...

Human Papillomavirus cause a number of diseases most notably cervical cancer. K14-HPV16 transgenic mice expressing the HPV16 early genes in squamous epithelial cells provide a suitable experimental model for studying these diseases. MicroRNAs are small non-coding RNAs that play an important role in regulating gene expression and have been suggested to play an important role in cancer developmen...

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with deep-seated lesions in the apocrine gland areas of body. Recruitment and activation innate adaptive immune cells around hair follicles drive initiation progression HS; however, nature cell populations underlying mechanisms remain unclear. scRNAseq revealed that NK CD4 T were major lymphocyte HS. Confocal microscopy showed...

DNA copy number variations (CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human disorders. Array comparative genomic hybridization has been used widely to identify CNVs genome wide, but the next-generation sequencing technology provides an opportunity to characterize CNVs genome wide with unprecedented resolution. In this st...

Cluster analysis is a multivariate statistical method, which is used to classify objects. It is used in many areas, such as the classification of customers or respondents in various marketing surveys. Individual objects are characterized by different variables. Variables can be quantitative and qualitative. Depending on the type of variables it is necessary to select the appropriate method of m...

A number of computational methods have been proposed for identifying transcription factor binding sites from a set of unaligned sequences that are thought to share the motif in question. We here introduce an algorithm, called cosmo, that allows this search to be supervised by specifying a set of constraints that the position weight matrix of the unknown motif must satisfy. Such constraints may ...