نتایج جستجو برای: mir 211
تعداد نتایج: 53662 فیلتر نتایج به سال:
Development of bone metastases is dependent on the cancer cell-bone cell interactions in the bone microenvironment. Transforming growth factor β (TGF-β) is released from bone during osteoclastic bone resorption and induces production of osteolytic factors, such as interleukin 11 (IL-11), in breast cancer cells. IL-11 in turn increases osteolysis by stimulating osteoclast function, launching a v...
Extracellular vesicles (EVs) play important roles in the diagnosis and treatment of diseases because its lavish bioinformatic molecular contents. However, how to separate plentiful extracellular a short time with high consistency is still problem. Here, we’d like introduce an automated capturing machine named EVenrich (Extracellular Vesicles Enrichment) that helps realize EVs biosamples high-th...
We introduce aligned hierarchies, a low-dimensional representation for music-based data streams, such as recordings of songs or digitized representations of scores. The aligned hierarchies encode all hierarchical decompositions of repeated elements from a high-dimensional and noisy music-based data stream into one object. These aligned hierarchies can be embedded into a classification space wit...
Here we report the synthesis, pharmacological and pharmacokinetic evaluation of a pilot set of compounds structurally related to the potent and selective 5-HT7 ligand LP-211. Among the studied compounds, N-pyridin-3-ylmethyl-3-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]ethoxy]propanamide (4b) showed high affinity for 5-HT7 receptors (K(i)=23.8 nM), selectivity over 5-HT1A receptors (>50-fold)...
Systems for the archival of musical documents digitally and development of digital music libraries are currently being researched and developed extensively. However, adapting these systems for the archival and retrieval of Malaysian music materials might not be as straightforward due to the distinct differences in musical structure and modes of non-Western music. This paper covers the motivatio...
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