نتایج جستجو برای: mir 122

تعداد نتایج: 60190  

Journal: :Journal of virology 2013
Selena M Sagan Peter Sarnow Joyce A Wilson

Hepatitis C virus (HCV) RNA forms an unusual interaction with human microRNA-122 (miR-122) that promotes viral RNA accumulation in cultured human liver cells and in the livers of infected chimpanzees. GB virus B (GBV-B) is a hepatotropic virus and close relative of HCV. Thus, GBV-B has been used as a surrogate system to study HCV amplification in cultured cells and in infected tamarins. It was ...

2016
Fanwei Liu Tetsuro Shimakami Kazuhisa Murai Takayoshi Shirasaki Masaya Funaki Masao Honda Seishi Murakami Minkyung Yi Hong Tang Shuichi Kaneko

Direct-acting antivirals (DAAs) against Hepatitis C virus (HCV) show effective antiviral activity with few side effects. However, the selection of DAA-resistance mutants is a growing problem that needs to be resolved. In contrast, miR-122 antagonism shows extensive antiviral effects among all HCV genotypes and a high barrier to drug resistance. In the present study, we evaluated three DAAs (sim...

2018
Abdel-Rahman N Zekri Enas Reda El-Sisi Amira Salah El-Din Youssef Mahmoud M Kamel Auhood Nassar Ola Sayed Ahmed Mohamed El Kassas Ahmed Barakat Barakat Alaa Ismail Abd El-Motaleb Abeer A Bahnassy

AIM Molecular characterization of the CD133+ stem cells associated with hepatocarinogensis through identifying the expression patterns of specific microRNAs (miRNAs). METHODS We investigated the expression pattern of 13 miRNAs in purified CD133+ cells separated from the peripheral blood of healthy volunteers, chronic hepatitis C (CHC), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) p...

2012
Hossein Sendi

The hepatic microRNA (miRNA), miR-122, is the most abundant miRNA within the liver, where it accounts for 70% of the total miRNA pool. It is known that miR-122, as an unusual host factor, increases the abundance of hepatitis C virus (HCV) RNA in HCV infection by binding directly to the 5'-UTR of the viral genome. Therefore, it has been suggested as a potential target for the treatment of hepati...

2014
Luca F. R. Gebert Mario A. E. Rebhan Silvia E. M. Crivelli Rémy Denzler Markus Stoffel Jonathan Hall

MicroRNAs (miRNAs) are short noncoding RNAs, which bind to messenger RNAs and regulate protein expression. The biosynthesis of miRNAs includes two precursors, a primary miRNA transcript (pri-miRNA) and a shorter pre-miRNA, both of which carry a common stem-loop bearing the mature miRNA. MiR-122 is a liver-specific miRNA with an important role in the life cycle of hepatitis C virus (HCV). It is ...

Journal: :Cellular & molecular immunology 2007
Shanshan Chen Ming Ni Bing Yu Tingting Lv Mengji Lu Feili Gong

MiR-122 is one of the non-coding RNAs which showed its effects on the lipo-metablism, virus infection and HCC forming through regulation of liver gene expression. Its eukaryotic expression vector was constructed by using pSuper which was widely applied in the siRNA expression. The precursor of human miR-122 gene was amplified by polymerase chain reaction (PCR) from the human genomic DNA. The po...

2015
Fu-Tao Zhao Yun Zhou Yong-Xing Zhou Qun Yang Le Song Xiao-Jing Jiang Zhan-Sheng Jia

BACKGROUND Liver-specific microRNA (miR)-122 has been shown to be involved in regulating translation of hepatitis C viral (HCV) RNA. This study aimed to explore the molecular mechanism of miR-122 in regulating HCV RNA translation initiation. MATERIAL/METHODS In human liver hepatocellular carcinoma cell line HepG2, UV cross-link assay was performed on a large scale to identify RNA-binding prot...

2016
Lei Song Zhongrui Zhang Jinling Zhang Xuebin Zhu Lei He Zhe Shi Li Gao Fumin Feng

Liver injury is a major hindrance to the treatment of tuberculosis (TB) patients due to the primary side effects associated with anti-TB drugs. Several investigations have identified sensitive biomarkers for the early diagnosis of anti-TB drug-induced liver injury (ADLI), including the use of microRNAs (miRNAs/miRs). However, the association between miR-122/155 and ADLI remains unknown. Thus, t...

2013
Laura Baselga-Escudero Anna Arola-Arnal Aïda Pascual-Serrano Aleix Ribas-Latre Ester Casanova M-Josepa Salvadó Lluis Arola Cinta Blade

miR-33 and miR-122 are major regulators of lipid metabolism in the liver, and their deregulation has been linked to the development of metabolic diseases such as obesity and metabolic syndrome. However, the biological importance of these miRNAs has been defined using genetic models. The aim of this study was to evaluate whether the levels of miR-122 and miR-33a in rat liver correlate with lipem...

Journal: :Nature communications 2016
Shenyi Yin Yu Fan Hanshuo Zhang Zhihua Zhao Yang Hao Juan Li Changhong Sun Junyu Yang Zhenjun Yang Xiao Yang Jian Lu Jianzhong Jeff Xi

Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservation of miR-122 in the TGFβ pathway: miR-122 target site is present in the mouse but not human TGFβR1, whereas a noncanonical target site is present in the TGFβ1 5'UTR in humans and other p...

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